Dieu Xavier, Tamareille Sophie, Herbreteau Aglae, Lebeau Lucie, Chao De La Barca Juan Manuel, Chabrun Floris, Reynier Pascal, Mirebeau-Prunier Delphine, Prunier Fabrice
MITOVASC, SFR ICAT, CNRS, INSERM, Université d'Angers, F-49000 Angers, France.
Service de Biochimie et Biologie Moléculaire, CHU Angers, F-49000 Angers, France.
Int J Mol Sci. 2023 Jul 26;24(15):12000. doi: 10.3390/ijms241512000.
Cardiac complications are frequently found following a stroke in humans whose pathophysiological mechanism remains poorly understood. We used machine learning to analyse a large set of data from a metabolipidomic study assaying 630 metabolites in a rat stroke model to investigate metabolic changes affecting the heart within 72 h after a stroke. Twelve rats undergoing a stroke and 28 rats undergoing the sham procedure were investigated. A plasmatic signature consistent with the literature with notable lipid metabolism remodelling was identified. The post-stroke heart showed a discriminant metabolic signature, in comparison to the sham controls, involving increased collagen turnover, increased arginase activity with decreased nitric oxide synthase activity as well as an altered amino acid metabolism (including serine, asparagine, lysine and glycine). In conclusion, these results demonstrate that brain injury induces a metabolic remodelling in the heart potentially involved in the pathophysiology of stroke heart syndrome.
在人类中，中风后经常会出现心脏并发症，但其病理生理机制仍知之甚少。我们使用机器学习分析了一项代谢脂质组学研究中的大量数据，该研究检测了大鼠中风模型中的630种代谢物，以调查中风后72小时内影响心脏的代谢变化。研究了12只中风大鼠和28只接受假手术的大鼠。确定了与文献一致的血浆特征，伴有显著的脂质代谢重塑。与假手术对照组相比，中风后的心脏表现出一种有区别的代谢特征，包括胶原蛋白周转增加、精氨酸酶活性增加、一氧化氮合酶活性降低以及氨基酸代谢改变（包括丝氨酸、天冬酰胺、赖氨酸和甘氨酸）。总之，这些结果表明，脑损伤会诱导心脏代谢重塑，这可能与中风后心脏综合征的病理生理学有关。
