State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Int J Mol Sci. 2023 Jul 28;24(15):12123. doi: 10.3390/ijms241512123.
Bile acids (BAs) are well known to facilitate the absorption of dietary fat and fat-soluble molecules. These unique steroids also function by binding to the ubiquitous cell membranes and nuclear receptors. As chemical signals in gut-liver axis, the presence of metabolic disorders such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM), and even tumors have been reported to be closely related to abnormal levels of BAs in the blood and fecal metabolites of patients. Thus, the gut microbiota interacting with BAs and altering BA metabolism are critical in the pathogenesis of numerous chronic diseases. This review intends to summarize the mechanistic links between metabolic disorders and BAs in gut-liver axis, and such stage-specific BA perturbation patterns may provide clues for developing new auxiliary diagnostic means.
胆汁酸（BAs）是众所周知的促进膳食脂肪和脂溶性分子的吸收。这些独特的甾体还通过与无处不在的细胞膜和核受体结合来发挥作用。作为肠肝轴的化学信号，存在代谢紊乱，如非酒精性脂肪性肝病（NAFLD）、2 型糖尿病（T2DM），甚至肿瘤，据报道与患者血液和粪便代谢物中 BAs 的异常水平密切相关。因此，与 BAs 相互作用并改变 BA 代谢的肠道微生物群在许多慢性疾病的发病机制中至关重要。本综述旨在总结肠肝轴中代谢紊乱与 BAs 之间的机制联系，这种特定阶段的 BA 扰动模式可能为开发新的辅助诊断手段提供线索。
