Department of Environmental Biology, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
NMR-Based Metabolomics Laboratory, "Sapienza" University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Molecules. 2023 Jul 25;28(15):5639. doi: 10.3390/molecules28155639.
(Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1-15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.
（斯特恩）皮尼亚蒂，又称撒丁岛长春花，广泛分布于意大利撒丁岛。该物种含有吲哚生物碱，已知具有多种生物活性。本研究调查了从在意大利的伊格莱西亚斯（撒丁岛）和罗马（拉齐奥）种植的植物中获得的富含生物碱的提取物对 B 淋巴母细胞系（SUP-B15）的抗白血病活性。所有提取物在测试浓度（1-15 µg/mL）下均显示出良好的抑制细胞增殖能力，可达 50%。此外，在所研究的浓度下，所有提取物对正常细胞均无细胞毒性。
