Bismuth Oxide Composite-Based Agricultural Waste for Wound Dressing Applications.

The purpose of this study was to enhance the antimicrobial activity of bagasse paper by coating the paper with bismuth oxide (BiO) and using it to accelerate the process of wound healing. Paper sheets were prepared from sugarcane waste (bagasse). First, the paper sheets were coated with different BiO concentrations to improve the antimicrobial activity of the paper. After that, the paper sheets were allowed to dry in an oven at 50 °C for 3 h. Then, in vitro antimicrobial activity was evaluated against different microbial species, including Gram-negative bacteria (i.e., Klebsiella pneumonia, Escherichia coli) and Gram-positive bacteria (i.e., Staphylococcus aureus, Streptococcus pyogenes). The obtained results showed that the paper coated with 25% and 100% BiO had activity against all models of bacteria; however, the paper coated with 100% BiO composite had the strongest inhibitory effect. Then, bagasse paper was coated with 100% BiO and different antibiotics, to investigate their wound-healing potency in a wounded rat model for 14 days. Moreover, the paper coated with 100% BiO inhibited the cellular migration in vitro. Conclusively, coating paper with BiO enhances the wound-healing potential when applied to wounds. This impact could be ascribed to BiO's broad antibacterial activity, which reduced infection and accelerated the healing process.