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基于四种营养评分的手术治疗股骨近端骨折患者死亡率的预测价值:一项回顾性数据分析。

Predictive Validity of Mortality after Surgically Treated Proximal Femur Fractures Based on Four Nutrition Scores-A Retrospective Data Analysis.

机构信息

Clinical Division of Traumatology, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, 1090 Vienna, Austria.

Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.

出版信息

Nutrients. 2023 Jul 28;15(15):3357. doi: 10.3390/nu15153357.

DOI:10.3390/nu15153357
PMID:37571292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10420813/
Abstract

BACKGROUND

Hip fractures are becoming a growing concern due to an aging population. The high costs to the healthcare system and far-reaching consequences for those affected, including a loss of independence and increased mortality rates, make this issue important. Poor nutritional status is a common problem among geriatric patients and is associated with a worse prognosis. Nutritional screening tools can help identify high-risk patients and enable individualized care to improve survival rates.

MATERIAL AND METHODS

This retrospective study investigates four nutritional scores and laboratory parameters' predictive significance concerning postoperative mortality after surgical treatment of proximal femur fractures at 1, 3, 6, and 12 month/s for patients over 60 years using the chi-square test, Cox regression analysis, and receiver operating characteristics (ROC). The European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines were used as part of the screening of the respective nutritional status of the patients, in particular to filter out malnutrition.

RESULTS

A total of 1080 patients were included in this study, whereas 8.05% suffered from malnutrition, defined as a body mass index (BMI) below 18.5 kg/m. The Mini Nutritional Assessment (MNA) screening tool identified the highest proportion of malnourished patients at 14.54%. A total of 36.39% of patients were at risk of malnutrition according to three nutrition scores, with MNA providing the most significant proportion at 41.20%. Patients identified as malnourished had a higher mortality rate, and MNA screening was the only tool to show a significant correlation with postoperative mortality in all survey intervals. The MNA presented the best predictive significance among the screening tools, with a maximum area under the curve (AUC) of 0.7 at 12 month postoperatively.

CONCLUSIONS

MNA screening has a solid correlation and predictive significance regarding postoperative mortality-therefore routine implementation of this screening in orthopedic/traumatology wards is recommended. Moreover, nutritional substitution therapy can offer a relatively inexpensive and easy-to-implement measure. The Graz malnutrition screening (GMS) shows moderate predictive power and could be considered as an alternative for patients under 60 years of age. A higher albumin level is associated with improved survival probability, but cannot be indicative of nutritional status.

摘要

背景

由于人口老龄化,髋部骨折成为一个日益严重的问题。这给医疗保健系统带来了高昂的成本,对患者造成了深远的影响,包括丧失独立性和死亡率上升,因此这个问题很重要。营养状况不佳是老年患者的常见问题,与预后较差有关。营养筛查工具可以帮助识别高危患者,并提供个性化护理以提高生存率。

材料和方法

本回顾性研究使用卡方检验、Cox 回归分析和受试者工作特征 (ROC) 分析了四种营养评分和实验室参数在 60 岁以上患者接受股骨近端骨折手术后 1、3、6 和 12 个月/时的术后死亡率的预测意义。欧洲临床营养和代谢学会 (ESPEN) 指南被用作患者营养状况筛查的一部分,特别是用于排除营养不良。

结果

共有 1080 名患者纳入本研究,其中 8.05%的患者患有营养不良,定义为 BMI 低于 18.5kg/m2。微型营养评估 (MNA) 筛查工具发现的营养不良患者比例最高,为 14.54%。根据三种营养评分,共有 36.39%的患者有营养不良风险,其中 MNA 提供的比例最高,为 41.20%。被认为营养不良的患者死亡率较高,MNA 筛查是唯一在所有调查间隔均与术后死亡率显著相关的工具。MNA 在筛查工具中具有最佳的预测意义,在术后 12 个月时的曲线下面积 (AUC) 最大,为 0.7。

结论

MNA 筛查与术后死亡率有很强的相关性和预测意义-因此,建议在矫形/创伤病房常规实施这种筛查。此外,营养替代治疗可以提供相对便宜且易于实施的措施。格拉茨营养不良筛查 (GMS) 具有中等的预测能力,可考虑用于 60 岁以下的患者。较高的白蛋白水平与生存概率的提高有关,但不能作为营养状况的指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/70e4c2333867/nutrients-15-03357-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/9ba3bb82e483/nutrients-15-03357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/4c04ea1b4e94/nutrients-15-03357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/fdcfaa9b7ab2/nutrients-15-03357-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/70e4c2333867/nutrients-15-03357-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/9ba3bb82e483/nutrients-15-03357-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/4c04ea1b4e94/nutrients-15-03357-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/fdcfaa9b7ab2/nutrients-15-03357-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112d/10420813/70e4c2333867/nutrients-15-03357-g004.jpg

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Prevalence, Characteristics, and Associated Risk Factors of the Elderly with Hip Fractures: A Cross-Sectional Analysis of NHANES 2005-2010.老年人髋部骨折的患病率、特征及相关危险因素:NHANES 2005-2010 的横断面分析。
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Hip Fractures.髋部骨折
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