抗性麦芽糊精和壳寡糖在慢性肾脏病肠道渗漏和微生物群管理中的作用
The Usefulness of Resistant Maltodextrin and Chitosan Oligosaccharide in Management of Gut Leakage and Microbiota in Chronic Kidney Disease.
作者信息
Anegkamol Weerapat, Kamkang Panumas, Hunthai Sittiphong, Kaewwongse Maroot, Taweevisit Mana, Chuaypen Natthaya, Rattanachaisit Pakkapon, Dissayabutra Thasinas
机构信息
Metabolic Disease in Gastrointestinal and Urinary System Research Unit, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
出版信息
Nutrients. 2023 Jul 28;15(15):3363. doi: 10.3390/nu15153363.
Microbiota-dysbiosis-induced gut leakage is a pathophysiologic change in chronic kidney disease (CKD), leading to the production of several uremic toxins and their absorption into the bloodstream to worsen the renal complications. We evaluate the benefits of resistant maltodextrin (RMD) and chitosan oligosaccharide (COS) supplements in cell culture and CKD-induced rats. The RMD exerted a significant anti-inflammatory effect in vitro and intestinal occludin and zonula occluden-1 up-regulation in CKD rats compared with inulin and COS. While all prebiotics slightly improved gut dysbiosis, RMD remarkably promoted the relative abundance and the combined abundance of , , , and in CKD rats. Supplements of RMD should be advantageous in the treatment of gut leakage and microbiota dysbiosis in CKD.
微生物群失调诱导的肠道渗漏是慢性肾脏病（CKD）中的一种病理生理变化，会导致多种尿毒症毒素的产生及其吸收入血，从而加重肾脏并发症。我们在细胞培养和CKD诱导的大鼠中评估了抗性麦芽糊精（RMD）和壳寡糖（COS）补充剂的益处。与菊粉和COS相比，RMD在体外具有显著的抗炎作用，并且能使CKD大鼠的肠道闭合蛋白和闭合小带蛋白-1上调。虽然所有益生元都能轻微改善肠道菌群失调，但RMD能显著提高CKD大鼠中[具体四种菌，原文未给出菌名]的相对丰度和综合丰度。补充RMD对治疗CKD中的肠道渗漏和微生物群失调应该是有益的。
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