Li Jinjie, Yang Ge, Zhang Qihe, Liu Zhuo, Jiang Xin, Xin Ying
Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University, Changchun, China.
Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, China.
Front Microbiol. 2023 Jun 15;14:1172400. doi: 10.3389/fmicb.2023.1172400. eCollection 2023.
The prevalence of type 2 diabetes (T2D) is increasing worldwide, with many patients developing long-term complications that affect their cardiovascular, urinary, alimentary, and other systems. A growing body of literature has reported the crucial role of gut microbiota in metabolic diseases, one of which, is considered the "next-generation probiotic" for alleviating metabolic disorders and the inflammatory response. Although extensive research has been conducted on , none has summarized its regulation in T2D. Hence, this review provides an overview of the effects and multifaceted mechanisms of on T2D and related diseases, including improving metabolism, alleviating inflammation, enhancing intestinal barrier function, and maintaining microbiota homeostasis. Furthermore, this review summarizes dietary strategies for increasing intestinal abundance and effective gastrointestinal delivery.
2型糖尿病（T2D）在全球的患病率正在上升，许多患者会出现影响其心血管、泌尿、消化和其他系统的长期并发症。越来越多的文献报道了肠道微生物群在代谢性疾病中的关键作用，其中一种被认为是缓解代谢紊乱和炎症反应的“下一代益生菌”。尽管已经对其进行了广泛研究，但尚未有人总结其在T2D中的调节作用。因此，本综述概述了其对T2D及相关疾病的影响和多方面机制，包括改善代谢、减轻炎症、增强肠道屏障功能和维持微生物群稳态。此外，本综述总结了增加肠道中其丰度的饮食策略和有效的胃肠道递送方法。
