Institute for Integrated Cell-Material Sciences (WPI-ICeMS), Institute for Advanced Study, Kyoto University, Kyoto, Japan.
Propharma Group, Japan.
Nutr Cancer. 2023;75(9):1710-1742. doi: 10.1080/01635581.2023.2242103. Epub 2023 Aug 12.
Colorectal cancer (CRC) accounts for considerable mortalities worldwide. Several modifiable risk factors, including a high intake of certain foods and beverages can cause CRC. This review summarized the latest findings on the intake of various foods, nutrients, ingredients, and beverages on CRC development, with the objective of classifying them as a risk or protective factor. High-risk food items include red meat, processed meat, eggs, high alcohol consumption, sugar-sweetened beverages, and chocolate candy. Food items that are protective include milk, cheese and other dairy products, fruits, vegetables (particularly cruciferous), whole grains, legumes (particularly soy beans), fish, tea (particularly green tea), coffee (particularly among Asians), chocolate, and moderate alcohol consumption (particularly wine). High-risk nutrients/ingredients include dietary fat from animal sources and industrial trans-fatty acids (semisolid/solid hydrogenated oils), synthetic food coloring, monosodium glutamate, titanium dioxide, and high-fructose corn sirup. Nutrients/ingredients that are protective include dietary fiber (particularly from cereals), fatty acids (medium-chain and odd-chain saturated fatty acids and highly unsaturated fatty acids, including omega-3 polyunsaturated fatty acids), calcium, polyphenols, curcumin, selenium, zinc, magnesium, and vitamins A, C, D, E, and B (particularly B, B, and B). A combination of micronutrients and multi-vitamins also appears to be beneficial in reducing recurrent adenoma incidence.
结直肠癌(CRC)在全球范围内造成了相当高的死亡率。一些可改变的风险因素,包括某些食物和饮料的高摄入量,可能导致 CRC。本综述总结了关于各种食物、营养素、成分和饮料摄入与 CRC 发展之间关系的最新发现,旨在将它们归类为风险或保护因素。高风险的食物包括红肉、加工肉、蛋类、高酒精摄入、含糖饮料和巧克力糖果。具有保护作用的食物包括牛奶、奶酪和其他乳制品、水果、蔬菜(特别是十字花科蔬菜)、全谷物、豆类(特别是大豆)、鱼类、茶(特别是绿茶)、咖啡(特别是在亚洲人中)、巧克力和适量饮酒(特别是葡萄酒)。高风险的营养素/成分包括来自动物来源的膳食脂肪和工业反式脂肪酸(半固态/固态氢化油)、合成食用色素、谷氨酸钠、二氧化钛和高果糖玉米糖浆。具有保护作用的营养素/成分包括膳食纤维(特别是来自谷物)、脂肪酸(中链和奇数链饱和脂肪酸和高度不饱和脂肪酸,包括ω-3 多不饱和脂肪酸)、钙、多酚、姜黄素、硒、锌、镁和维生素 A、C、D、E 和 B(特别是 B、B 和 B)。微量营养素和多种维生素的组合似乎也有益于降低复发性腺瘤的发生率。