Guo Yongyan, Zhang Jiabao, Liu Jinying, Wang Nan, Su Xingguang
Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, PR China.
Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, PR China.
Anal Chim Acta. 2023 Oct 2;1276:341649. doi: 10.1016/j.aca.2023.341649. Epub 2023 Jul 20.
Here, a novel fluorescent sensing strategy is established for the detection of captopril (CP) sensitively on the basis of a nanocomposite of gold nanoclusters (AuNCs) and metal-organic framework (AuNCs@ZIF-8). The aggregation-induced emission (AIE) effect will be triggered when AuNCs is encapsulated by metal-organic framework (MOF) which served as a carrier since it limits the molecular motion of AuNCs, and the fluorescence of AuNCs greatly enhanced about 5-time after forming the nanocomposites of AuNCs@ZIF-8. The strong orange-emission at 562 nm was quenched in the presence of mercury ions through dynamic quenching. After adding captopril, the quenched fluorescence of AuNCs@ZIF-8/Hg system would be restored due to the specific interaction among captopril with mercury ions. Simultaneously, the restored degree of AuNCs@ZIF-8/Hg fluorescence depended on the concentration of captopril. Hence, with AuNCs@ZIF-8 serving as reporter signal, the captopril content can be monitored by an "on-off-on" fluorescence sensing mode with a linear relationship of 1-100 μM, and the limit of detection for captopril was 0.134 μM.
在此，基于金纳米簇（AuNCs）与金属有机框架（AuNCs@ZIF-8）的纳米复合材料，建立了一种新颖的荧光传感策略，用于灵敏检测卡托普利（CP）。当AuNCs被用作载体的金属有机框架（MOF）包裹时，会触发聚集诱导发光（AIE）效应，因为它限制了AuNCs的分子运动，并且在形成AuNCs@ZIF-8纳米复合材料后，AuNCs的荧光大大增强了约5倍。在汞离子存在下，562 nm处的强橙色发射通过动态猝灭被猝灭。加入卡托普利后，由于卡托普利与汞离子之间的特异性相互作用，AuNCs@ZIF-8/Hg体系猝灭的荧光将恢复。同时，AuNCs@ZIF-8/Hg荧光的恢复程度取决于卡托普利的浓度。因此，以AuNCs@ZIF-8作为报告信号，卡托普利含量可通过“开-关-开”荧光传感模式进行监测，线性关系为1-100 μM，卡托普利的检测限为0.134 μM。
