Cheng H H, Wang D Q, Minuk G Y, Anand C M, Stowe T C, Buchan K A
Clin Invest Med. 1986;9(3):156-9.
To assess the prevalence and pathological role of hepatitis D virus (HDV) infection in western Canada, we tested a total of 310 sera from the province of Alberta, Yukon and Northwest Territories for antibody to HD (anti-HDV) by commercial solid phase radioimmunoassay. Two hundred and forty-five sera were hepatitis B surface antigen (HBsAg) positive. These were classified on the basis of clinical and biochemical data as either acute hepatitis, chronic hepatitis or in the healthy carrier phase of infection Sixty-five HBsAg negative sera from patients with other forms of chronic liver diseases served as controls. Anti-HDV was detected in only four of the HBsAg positive sera (1.6%) and in none of the controls. The prevalence of anti-HDV was significantly higher in patients with chronic hepatitis, three of twenty-two (13.6%) than in patients with acute hepatitis (0%) (p less than 0.05) or healthy carriers (0%) (p less than 0.005). Two of the four anti-HDV positive sera were obtained from patients with a history of parenteral drug abuse. These results indicate that HDV infection is uncommon in western Canada but, when it does occur, is more likely to be associated with chronic inflammatory liver disease. Parenteral drug abuse appears to be the major risk factor for HDV infection in western Canada at this time.
为评估丁型肝炎病毒（HDV）感染在加拿大西部的流行情况及其病理作用，我们采用商业固相放射免疫分析法，对来自艾伯塔省、育空地区和西北地区的总共310份血清进行了丁型肝炎抗体（抗-HDV）检测。245份血清乙型肝炎表面抗原（HBsAg）呈阳性。根据临床和生化数据，这些血清被分类为急性肝炎、慢性肝炎或处于感染的健康携带者阶段。来自患有其他形式慢性肝病患者的65份HBsAg阴性血清用作对照。仅在4份HBsAg阳性血清（1.6%）中检测到抗-HDV，而在对照血清中均未检测到。慢性肝炎患者中抗-HDV的流行率显著高于急性肝炎患者（0%）（p<0.05）或健康携带者（0%）（p<0.005），22例慢性肝炎患者中有3例（13.6%）。4份抗-HDV阳性血清中有2份来自有静脉注射毒品滥用史的患者。这些结果表明，HDV感染在加拿大西部并不常见，但一旦发生，更可能与慢性炎症性肝病相关。静脉注射毒品滥用目前似乎是加拿大西部HDV感染的主要危险因素。
