Chou Ming-Yu, Wong Yue-Ching, Wang Shih-Yi, Chi Ching-Hsin, Wang Teng-Hsu, Huang Mao-Jung, Huang Ping-Hsiu, Li Po-Hsien, Wang Ming-Fu
School of Business, Qanzhou Vocational and Technical University, Jinjiang, China.
International Aging Industry Research & Development Center (AIC), Providence University, Taichung, Taiwan (R.O.C.).
Front Nutr. 2023 Jul 28;10:1235780. doi: 10.3389/fnut.2023.1235780. eCollection 2023.
Healthcare is an emerging industry with significant market potential in the 21st century. Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its complexes for 8 weeks on 3-month-old senescence-accelerated mouse prone-8 (SAMP8) mice, 48 in total, randomly divided into 3 groups including control, Huáng qí extract [820 mg/kg Body weight (BW)/day], and Huáng qí complexes (6.2 mL /kg BW/day), where each group consisted of males ( = 8) and females ( = 8). Behavioral tests (locomotion test and aging score assessment on week 6, the single-trial passive avoidance test on week 7, and the active shuttle avoidance test on week 8) were conducted to evaluate the ability of the mice to learn and remember. In addition, after sacrificing the animals, the blood and organs were measured for antioxidant and aging bioactivities, including malondialdehyde (MDA) content and superoxide dismutase (SOD) activity and catalase activities (CAT), and the effects on promoting aging in SAMP8 mice were investigated. The findings showed that Huáng qí enhanced locomotor performance and had anti-aging effects, with positive effects on health, learning, and memory in SAMP-8 mice ( < 0.05), whether applied as a single agent (820 mg/kg BW/day) or as a complex (6.2 mL/kg BW/day) ( < 0.05). Based on existing strengths, a more compelling platform for clinical validation of human clinical evidence will be established to enhance the development and value-added of astragalus-related products while meeting the diversified needs of the functional food market.
医疗保健是21世纪具有巨大市场潜力的新兴产业。因此，本研究旨在评估对3月龄快速老化小鼠易感8型（SAMP8）小鼠连续8周经管饲黄芪及其复合物的益处，总共48只小鼠，随机分为3组，包括对照组、黄芪提取物[820毫克/千克体重（BW）/天]和黄芪复合物（6.2毫升/千克BW/天），每组由雄性（=8只）和雌性（=8只）组成。进行行为测试（第6周的运动测试和衰老评分评估、第7周的单次被动回避测试以及第8周的主动穿梭回避测试）以评估小鼠的学习和记忆能力。此外，在处死动物后，测量血液和器官的抗氧化和衰老生物活性，包括丙二醛（MDA）含量、超氧化物歧化酶（SOD）活性和过氧化氢酶活性（CAT），并研究其对SAMP8小鼠促衰老的影响。研究结果表明，无论作为单一制剂（820毫克/千克BW/天）还是作为复合物（6.2毫升/千克BW/天）应用，黄芪均能增强运动性能并具有抗衰老作用，对SAMP - 8小鼠的健康、学习和记忆有积极影响（<0.05）（<0.05）。基于现有优势，将建立一个更具说服力的平台用于人体临床证据的临床验证，以促进黄芪相关产品的开发和增值，同时满足功能性食品市场的多样化需求。
