Wu Mingda, Dong Cuiting, Yang Zhen, Song Yongfu, Xu Chenkai, Ma Shuang, Lan Yuejiao, Lu Xiaodan
Precision Medicine Center, Jilin Province People's Hospital, Changchun, Jilin, 130021, China.
Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China.
Heliyon. 2024 Oct 11;10(20):e39230. doi: 10.1016/j.heliyon.2024.e39230. eCollection 2024 Oct 30.
Oxidative stress is closely associated with the estimated glomerular filtration rate (eGFR) levels. A comprehensive indicator for evaluating dietary and lifestyle exposures to oxidative stress is the Oxidative Balance Score (OBS), with higher OBS suggesting more substantial antioxidant exposures. The aim of this study is to explore the relationship between OBS and eGFR levels. A total of 20,285 subjects were selected from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. One-way and multifactorial linear regression analyses were used to assess the association of OBS with eGFR. The relationship between OBS and eGFR levels was also assessed using restricted cubic splines (RCS) analysis. OBS levels were significantly and positively correlated with eGFR levels, and eGFR values were more susceptible to OBS in males than in females. Our findings suggest that higher OBS scores may be associated with higher eGFR levels, highlighting the importance of adhering to an antioxidant diet and lifestyle, which can help prevent kidney disease.
氧化应激与估算肾小球滤过率（eGFR）水平密切相关。氧化平衡评分（OBS）是评估饮食和生活方式中氧化应激暴露的一项综合指标，OBS越高表明抗氧化剂暴露越充分。本研究旨在探讨OBS与eGFR水平之间的关系。从2007年至2018年的美国国家健康与营养检查调查（NHANES）中选取了总共20285名受试者。采用单因素和多因素线性回归分析来评估OBS与eGFR的关联。还使用受限立方样条（RCS）分析评估了OBS与eGFR水平之间的关系。OBS水平与eGFR水平显著正相关，并且男性的eGFR值比女性更容易受到OBS的影响。我们的研究结果表明，较高的OBS评分可能与较高的eGFR水平相关，这突出了坚持抗氧化饮食和生活方式的重要性，这有助于预防肾脏疾病。
