Shan Zhengming, Xie Xinhui, Wu Xiaotao, Zhuang Suyang, Zhang Cong
School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, China.
The Department of Orthopaedics, ZhongDa Hospital, Nanjing, Jiangsu, 210009, China.
J Orthop Translat. 2022 Oct 8;36:184-193. doi: 10.1016/j.jot.2022.09.013. eCollection 2022 Sep.
Use of degradable magnesium (Mg)-based metal implants in orthopaedic surgeries can avoid drawbacks associated with subsequent removal of the non-degradable metallic implants, reducing cost and trauma of patients. Although Mg has been applied in the clinic for orthopaedic treatment, the use of Mg-based metal implants is largely in the research phase. But its application is potentially beneficial in this context as it has been shown that Mg can promote osteogenesis and inhibit osteoclast activity.
A systematic literature search about "degradable magnesium (Mg)-based metal implants" was performed in PubMed and Web of Science. Meanwhile, relevant findings have been reviewed and quoted.
In this review, we summarize the latest developments in Mg-based metal implants and their role in bone regeneration. We also review the various molecular mechanisms by which Mg ions regulate bone metabolic processes, including osteogenesis, osteoclast activity, angiogenesis, immunity, and neurology. Finally, we discuss the remaining research challenges and opportunities for Mg-based implants and their applications.
Currently, establishment of the in vitro and in vivo biological evaluation systems and phenotypic modification improvement of Mg-based implants are still needed. Clarifying the functions of Mg-based metal implants in promoting bone metabolism is beneficial for their clinical application.
All current reviews on Mg-based implants are mainly concerned with the improvement of Mg alloy properties or the progress of applications. However, there are few reviews that provides a systematic narrative on the effect of Mg on bone metabolism. This review summarized the latest developments in Mg-based metal implants and various molecular mechanisms of Mg ions regulating bone metabolism, which is beneficial to further promote the translation of Mg based implants in the clinic and is able to provide a strong basis for the clinical application of Mg based implants.
在骨科手术中使用可降解镁基金属植入物可避免与后续取出不可降解金属植入物相关的缺点，降低患者的成本和创伤。尽管镁已在临床上用于骨科治疗，但镁基金属植入物的使用大多仍处于研究阶段。但在这种情况下其应用可能有益，因为已表明镁可促进成骨并抑制破骨细胞活性。
在PubMed和Web of Science上对“可降解镁基金属植入物”进行了系统的文献检索。同时，对相关研究结果进行了综述和引用。
在本综述中，我们总结了镁基金属植入物的最新进展及其在骨再生中的作用。我们还综述了镁离子调节骨代谢过程的各种分子机制，包括成骨、破骨细胞活性、血管生成、免疫和神经学。最后，我们讨论了镁基植入物及其应用中 remaining research challenges and opportunities。
目前，仍需要建立镁基植入物的体外和体内生物学评估系统以及表型修饰改进。阐明镁基金属植入物在促进骨代谢中的作用有利于其临床应用。
目前所有关于镁基植入物的综述主要关注镁合金性能的改进或应用进展。然而，很少有综述对镁对骨代谢的影响进行系统的叙述。本综述总结了镁基金属植入物的最新进展以及镁离子调节骨代谢的各种分子机制，有利于进一步推动镁基植入物在临床上的转化，并能够为镁基植入物的临床应用提供有力依据。
