Alwafi Hassan
Pharmacology and Toxicology Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Saudi Pharm J. 2023 Aug;31(8):101670. doi: 10.1016/j.jsps.2023.06.003. Epub 2023 Jun 12.
This study aimed to investigate the trend of hospital admissions related to poisoning by narcotics and psychodysleptics and poisoning by antiepileptic, sedative-hypnotic, and antiparkinsonism drugs in England and Wales between April 1999 and April 2020.
An observational ecological study were conducted using data from the Hospital Episode Statistics database in England and the Patient Episode Database for Wales. The rate of hospital admissions with 95% confidence intervals (CIs) was calculated by dividing the number of episodes of poisoning by narcotics and psychodysleptics related admission and poisoning by antiepileptic, sedative-hypnotic, and antiparkinsonism drugs-related admission by the mid-year population from the Office for National Statistics. All analyses were conducted using SPSS version 27.
The total annual number of hospital admissions for narcotics and psychodysfunctionals poisonings increased by 1.40-fold [from 15.70 (95% CI 15.36-16.04) in 1999 to 37.64 (95% CI 37.15-38.13) in 2020 per 100,000 people, p < 0.01]. However, the overall annual number of poisonings by antiepileptic, sedative-hypnotic and antiparkinsonism drugs hospital admissions for various reasons decreased by 12.8% [from 33.55 (95% CI 33.05-34.04) in 1999 to 29.26 (95% CI 28.82-29.69) in 2020 per 100,000 persons, p < 0.05]. Poisoning by other opioids (53.2%), heroin (15.1%), and other synthetic narcotics (13.3%) were the most common reasons for narcotic and psychodysfunctional poisoning. While poisoning by benzodiazepines (54.2%) and poisoning: other antiepileptic and sedative-hypnotic drugs (30.7%) were the most common hospital admission reasons for poisoning by antiepileptic, sedative-hypnotic, and antiparkinsonism.
Poisoning by narcotics have increased in England and Wales over the study period, however, poisoning by antiepileptic, sedative-hypnotic, and antiparkinsonism drugs in England and Wales were relatively stable during the same period. Future initiatives and awareness programs to prevent harmful use and drug poisoning by narcotics, sedative-hypnotic and other medications are needed.
本研究旨在调查1999年4月至2020年4月期间，英格兰和威尔士与麻醉药品和精神药品中毒以及抗癫痫药、镇静催眠药和抗帕金森病药物中毒相关的住院趋势。
采用英格兰医院事件统计数据库和威尔士患者事件数据库的数据进行观察性生态研究。通过将麻醉药品和精神药品相关中毒入院事件数以及抗癫痫药、镇静催眠药和抗帕金森病药物相关中毒入院事件数除以国家统计局年中人口数，计算出95%置信区间（CI）的住院率。所有分析均使用SPSS 27版进行。
麻醉药品和精神功能障碍中毒的年度住院总数增加了1.40倍[从1999年的每10万人中15.70例（95%CI 15.36 - 16.04）增加到2020年的每10万人中37.64例（95%CI 37.15 - 38.13），p < 0.01]。然而，抗癫痫药、镇静催眠药和抗帕金森病药物因各种原因导致的中毒年度住院总数下降了12.8%[从1999年的每10万人中33.55例（95%CI 33.05 - 34.04）下降到2020年的每10万人中29.26例（95%CI 28.82 - 29.69），p < 0.05]。其他阿片类药物中毒（53.2%）、海洛因中毒（15.1%）和其他合成麻醉药品中毒（13.3%）是麻醉药品和精神功能障碍中毒的最常见原因。而苯二氮䓬类药物中毒（54.2%）以及其他抗癫痫药和镇静催眠药中毒（30.7%）是抗癫痫药、镇静催眠药和抗帕金森病药物中毒最常见的住院原因。
在研究期间，英格兰和威尔士的麻醉药品中毒有所增加，然而，同期英格兰和威尔士的抗癫痫药、镇静催眠药和抗帕金森病药物中毒相对稳定。需要未来采取举措并开展宣传项目，以预防麻醉药品、镇静催眠药和其他药物的有害使用和药物中毒。
