Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan.
Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
BMC Prim Care. 2022 Sep 16;23(1):239. doi: 10.1186/s12875-022-01853-1.
Medication use assessment has a critical role in promoting the effective and rational use of pharmaceutical medications. There are no studies that have explored the utilization of all medications in England and Wales in the past 15 years without restrictions in the age group being studied or class of medications.
To explore the medication utilization pattern of dispensed medications in England and Wales in the past 15 years.
A secular trend analysis study using publically available dispensing data on the population level in England and Wales for the duration between 2004 and 2019. Medication dispensing data was extracted from the Prescription Cost Analysis database.
Medication prescriptions rate increased by 42.6% [from 1,345,095.75 (95% CI 1,345,004.25 - 1,345,187.26) in 2004 to 1,918,138.48 (95% CI 1,918,038.38 - 1,918,238.57) in 2019 per 100,000 persons, trend test, p < 0.001]. During the study period, the most common medication prescriptions were for the cardiovascular system, central nervous system, and endocrine system, which accounted for 30.2%, 18.8%, and 9.4%, respectively. The rate of medication prescriptions for skin, immunological products and vaccines, infections, and musculoskeletal and joint diseases decreased by 18.4%, 15.8%, 9.8%, and 5.7%, respectively.
The last two decades have witnessed a remarkable rise in the quantity of medications dispensed in community settings. Utilization of chronic disease medications has increased in the past 15 years, specifically, dispensed medications for the cardiovascular system, central nervous system, and endocrine system. It is necessary to conduct additional cohort studies to investigate the clinical outcomes and prescribing safety of these medications.
药物使用评估在促进药物的有效和合理使用方面具有关键作用。过去 15 年，没有研究在不限制研究年龄组或药物类别的情况下，探索过英格兰和威尔士所有药物的使用情况。
探讨过去 15 年英格兰和威尔士配药药物的使用模式。
一项基于人群的、利用英格兰和威尔士在 2004 年至 2019 年期间公开可得的配药数据进行的长期趋势分析研究。药物配药数据从处方成本分析数据库中提取。
药物处方率增长了 42.6%[从 2004 年的每 10 万人 1,345,095.75（95%置信区间 1,345,004.25-1,345,187.26）增加到 2019 年的每 10 万人 1,918,138.48（95%置信区间 1,918,038.38-1,918,238.57），趋势检验，p<0.001]。在研究期间，最常见的药物处方是心血管系统、中枢神经系统和内分泌系统，分别占 30.2%、18.8%和 9.4%。皮肤、免疫产品和疫苗、感染、肌肉骨骼和关节疾病的药物处方率分别下降了 18.4%、15.8%、9.8%和 5.7%。
过去二十年，社区环境中配出的药物数量显著增加。在过去的 15 年中，慢性病药物的使用有所增加，特别是心血管系统、中枢神经系统和内分泌系统的配药药物。有必要进行更多的队列研究，以调查这些药物的临床结果和处方安全性。
