Keating Shelley E, Croci Ilaria, Wallen Matthew P, Cox Emily R, Coombes Jeff S, Burton Nicola W, Macdonald Graeme A, Hickman Ingrid J
Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia.
K.G. Jebsen Center of Exercise in Medicine Norwegian University of Science and Technology, Department of Circulation and Medical Imaging, Faculty of Medicine, Trondheim, Norway.
J Clin Transl Hepatol. 2023 Oct 28;11(5):1050-1060. doi: 10.14218/JCTH.2022.00091S. Epub 2023 Apr 21.
High-intensity interval training (HIIT) is a therapeutic option for people with nonalcoholic steatohepatitis (NASH). However, the perspectives and experiences of HIIT for people with NASH are unknown, limiting translation of research. We explored the experiences and perspectives of both professionally supervised and self-directed HIIT in people with NASH and evaluated participant-reported knowledge, barriers, and enablers to commencing and sustaining HIIT.
Twelve participants with NASH underwent 12 weeks of supervised HIIT (3 days/week, 4×4 minutes at 85-95% maximal heart rate, interspersed with 3 minutes active recovery), followed by 12-weeks of self-directed (unsupervised) HIIT. One-on-one, semistructured participant interviews were conducted by exercise staff prior to HIIT and following both supervised and self-directed HIIT to explore prior knowledge, barriers, enablers, and outcomes at each stage. Interviews were audio-recorded, transcribed, coded, and thematically analyzed by two independent researchers.
Four dominant themes were identified: (1) no awareness of/experience with HIIT and ambivalence about exercise capabilities; (2) multiple medical and social barriers to commencing and continuing HIIT; (3) exercise specialist support was a highly valued enabler, and (4) HIIT was enjoyed and provided holistic benefits.
People with NASH may lack knowledge of and confidence for HIIT, and experience multiple complex barriers to commencing and continuing HIIT. Exercise specialist support is a key enabler to sustained engagement. These factors need to be addressed in future clinical programs to augment the uptake and long-term sustainability of HIIT by people with NASH so they can experience the range of related benefits.
高强度间歇训练（HIIT）是治疗非酒精性脂肪性肝炎（NASH）患者的一种选择。然而，NASH患者对HIIT的看法和体验尚不清楚，这限制了相关研究成果的转化。我们探讨了NASH患者在专业监督和自主进行HIIT方面的体验和看法，并评估了参与者报告的开始和持续进行HIIT的知识、障碍和促进因素。
12名NASH患者接受了为期12周的监督HIIT（每周3天，85-95%最大心率下进行4×4分钟，中间穿插3分钟主动恢复），随后是12周的自主（无监督）HIIT。在HIIT之前以及监督和自主HIIT之后，由运动工作人员对参与者进行一对一的半结构化访谈，以探讨每个阶段的先验知识、障碍、促进因素和结果。访谈进行录音、转录、编码，并由两名独立研究人员进行主题分析。
确定了四个主要主题：（1）对HIIT缺乏认识/经验以及对运动能力存在矛盾心理；（2）开始和持续进行HIIT存在多种医学和社会障碍；（3）运动专家的支持是一个非常重要的促进因素；（4）患者喜欢HIIT并从中获得全面益处。
NASH患者可能对HIIT缺乏了解和信心，并且在开始和持续进行HIIT时会遇到多种复杂障碍。运动专家的支持是持续参与的关键促进因素。在未来的临床项目中需要解决这些因素，以提高NASH患者对HIIT的接受度和长期可持续性，使他们能够体验到一系列相关益处。
