Smith J E
Academic Department of Sports Medicine, Royal London Hospital (Mile End), Bancroft Road, London E1, UK.
Br J Sports Med. 2003;37(5):433-5. doi: 10.1136/bjsm.37.5.433.
To review the effects of exercise on haemostasis and examine the possible clinical sequelae of these changes.
The search strategy included articles from 1966 to August 2002 using Medline and SportDiscus databases, and cross referencing the bibliographies of relevant papers.
Exercise results in activation of both the coagulation and fibrinolytic cascades, as shown by a reduction in whole blood clotting time and activated partial thromboplastin time, an increase in the activity of several components of the cascades, and an increase in fibrin degradation products. In vitro tests suggest that coagulation remains activated after fibrinolysis has returned to baseline levels.
Both the coagulation and fibrinolytic cascades are stimulated by strenuous exercise, but the temporal relation between the two and its clinical significance remains to be clarified. Doctors and athletes should be aware of the haemostatic changes induced by exercise, and further work is needed to clarify the possible role of these changes in sudden cardiac death.
回顾运动对止血的影响，并研究这些变化可能产生的临床后果。
检索策略包括使用Medline和SportDiscus数据库查找1966年至2002年8月的文章，并交叉引用相关论文的参考文献。
运动导致凝血和纤溶级联反应激活，表现为全血凝固时间和活化部分凝血活酶时间缩短、级联反应中几个成分的活性增加以及纤维蛋白降解产物增加。体外试验表明，纤溶回到基线水平后凝血仍处于激活状态。
剧烈运动可刺激凝血和纤溶级联反应，但两者之间的时间关系及其临床意义仍有待阐明。医生和运动员应意识到运动引起的止血变化，还需要进一步研究以阐明这些变化在心脏性猝死中可能发挥的作用。
