Yokosuka Ryohsuke, Ikeya Takashi, Yamato Hiroshi, Kanomata Naoki, Fukuda Katsuyuki
Department of Gastroenterology, St. Luke's International Hospital, Tokyo, Japan.
Department of Pathology, St. Luke's International Hospital, Tokyo, Japan.
ACG Case Rep J. 2023 Aug 14;10(8):e01110. doi: 10.14309/crj.0000000000001110. eCollection 2023 Aug.
Perineurioma is a relatively rare tumor with an occasionally difficult differential diagnosis. A 63-year-old woman underwent esophagogastroduodenoscopy, which revealed a 15 mm, slightly faded, flat, and elevated lesion in the gastric body. Biopsy revealed a bundle-like proliferation of spindle-shaped cells; however, the diagnosis was unconfirmed. Endoscopic submucosal dissection was performed for diagnosis and treatment. Histopathological examination of the lesion revealed cell proliferation with short spindle-shaped and oval nuclei and little atypia in the lamina propria. Immunohistochemical examination indicated a perineurioma. Thus, when spindle-shaped cells are found on biopsy, it is necessary to consider the possibility of perineurioma.
神经束膜瘤是一种相对罕见的肿瘤，鉴别诊断有时存在困难。一名63岁女性接受了食管胃十二指肠镜检查，结果显示胃体部有一个15毫米、颜色略淡、扁平且隆起的病变。活检显示梭形细胞呈束状增生；然而，诊断尚未得到证实。为明确诊断和进行治疗，实施了内镜下黏膜下剥离术。对病变进行组织病理学检查，结果显示固有层内细胞增生，细胞核呈短梭形和椭圆形，异型性较小。免疫组织化学检查提示为神经束膜瘤。因此，活检发现梭形细胞时，有必要考虑神经束膜瘤的可能性。
