Analysis of antibacterial and cytotoxic potential of medicinal plants from Cholistan desert, Pakistan.

This study aimed to investigate the antibacterial and cytotoxic activity of 03 medicinal plants, , and from Cholistan desert, Pakistan. The active constituents of plants species were extracted in 05 different solvents and the extracts were tested against various bacterial strains and brine shrimps. Although all 's extracts except chloroform were active against the most active was the acetone extract (21 ± 0.00 mm at 200 μg/disc) and activity was better than Caricef (p-value 0.03). While its water extract was more potent (18 ± 1.45 mm at 200 μg/disc) than Augmentin and Caricef (p-value < 0.005). The methanol extract's activity (15 ± 0.39 mm in 200 μg/disc) was comparable to Fucidin against (p-value > 0.99) and activity of diethyl ether extract against (10 ± 1.16 mm in 200 μg/disc) was same as of Urixin (p-value 0.91)'s acetone extract against (10 ± 0.15 mm in 1 μg/disc) was more active than Augmentin Caricef and Cefotax (p-value < 0.02) and against (15 ± 1.15 mm in 200 μg/disc) activity was higher than Caricef (p-value 0.03). All 's extracts except water extract were found active against However, the diethyl ether extract was most effective (25 + 0.00 mm at 150 μg /disc) and activity was more than Augmentin, Oxy-tetracycline, Fucidin, Urixin, Ceftriaxone (p-value < 0.05). Although all extracts were exhibited cytotoxic activity, the 's acetone extract (100%), 's diethyl ether extract (90%) and 's methanol extract (100%) were most active at 1000 μg/ml concentration. This study validated the medicinal significance of the studied plants and thus opens the way for their therapeutic applications.