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胎儿镜检查的导航框架研究。

Toward a navigation framework for fetoscopy.

机构信息

Department of Advanced Robotics, Istituto Italiano di Tecnologia, Genoa, Italy.

Department of Electronic, Information and Bioengineering, Politecnico di Milano, Milan, Italy.

出版信息

Int J Comput Assist Radiol Surg. 2023 Dec;18(12):2349-2356. doi: 10.1007/s11548-023-02974-3. Epub 2023 Aug 16.

DOI:10.1007/s11548-023-02974-3
PMID:37587389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10632301/
Abstract

PURPOSE

Fetoscopic laser photocoagulation of placental anastomoses is the most effective treatment for twin-to-twin transfusion syndrome (TTTS). A robust mosaic of placenta and its vascular network could support surgeons' exploration of the placenta by enlarging the fetoscope field-of-view. In this work, we propose a learning-based framework for field-of-view expansion from intra-operative video frames.

METHODS

While current state of the art for fetoscopic mosaicking builds upon the registration of anatomical landmarks which may not always be visible, our framework relies on learning-based features and keypoints, as well as robust transformer-based image-feature matching, without requiring any anatomical priors. We further address the problem of occlusion recovery and frame relocalization, relying on the computed features and their descriptors.

RESULTS

Experiments were conducted on 10 in-vivo TTTS videos from two different fetal surgery centers. The proposed framework was compared with several state-of-the-art approaches, achieving higher [Formula: see text] on 7 out of 10 videos and a success rate of [Formula: see text] in occlusion recovery.

CONCLUSION

This work introduces a learning-based framework for placental mosaicking with occlusion recovery from intra-operative videos using a keypoint-based strategy and features. The proposed framework can compute the placental panorama and recover even in case of camera tracking loss where other methods fail. The results suggest that the proposed framework has large potential to pave the way to creating a surgical navigation system for TTTS by providing robust field-of-view expansion.

摘要

目的

胎盘吻合处的胎儿镜激光光凝是治疗双胎输血综合征(TTTS)最有效的方法。胎盘及其血管网络的强大马赛克可以通过扩大胎儿镜的视野来支持外科医生对胎盘的探索。在这项工作中,我们提出了一种基于学习的框架,用于从术中视频帧扩展视野。

方法

虽然当前的胎儿镜马赛克技术基于解剖学标志的注册,而这些标志并不总是可见的,但我们的框架依赖于基于学习的特征和关键点,以及基于稳健的转换器的图像特征匹配,而不需要任何解剖学先验知识。我们进一步解决了遮挡物恢复和帧重新定位的问题,依赖于计算出的特征及其描述符。

结果

在来自两个不同胎儿手术中心的 10 个体内 TTTS 视频上进行了实验。将所提出的框架与几种最先进的方法进行了比较,在 10 个视频中的 7 个视频上实现了更高的[公式:见文本],并且遮挡物恢复的成功率达到了[公式:见文本]。

结论

这项工作介绍了一种基于学习的框架,用于使用基于关键点的策略和特征从术中视频中进行带有遮挡物恢复的胎盘马赛克处理。所提出的框架可以计算胎盘全景图,即使在其他方法失败的情况下,也可以在摄像机跟踪丢失的情况下进行恢复。结果表明,该框架具有很大的潜力,可以通过提供稳健的视野扩展,为 TTTS 创建手术导航系统铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ec/10632301/4e39dd51d59a/11548_2023_2974_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ec/10632301/0bd6dda8e2ea/11548_2023_2974_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ec/10632301/86dc6aaedbe5/11548_2023_2974_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ec/10632301/4e39dd51d59a/11548_2023_2974_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ec/10632301/0bd6dda8e2ea/11548_2023_2974_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ec/10632301/86dc6aaedbe5/11548_2023_2974_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42ec/10632301/4e39dd51d59a/11548_2023_2974_Fig4_HTML.jpg

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本文引用的文献

1
Histogram of Oriented Gradients meet deep learning: A novel multi-task deep network for 2D surgical image semantic segmentation.方向梯度直方图与深度学习的结合:一种用于 2D 手术图像语义分割的新型多任务深度网络。
Med Image Anal. 2023 Apr;85:102747. doi: 10.1016/j.media.2023.102747. Epub 2023 Jan 13.
2
Robust fetoscopic mosaicking from deep learned flow fields.基于深度学习流场的稳健羊膜镜拼接。
Int J Comput Assist Radiol Surg. 2022 Jun;17(6):1125-1134. doi: 10.1007/s11548-022-02623-1. Epub 2022 May 3.
3
A shape-constraint adversarial framework with instance-normalized spatio-temporal features for inter-fetal membrane segmentation.
用于胎儿膜分割的具有实例归一化时空特征的形状约束对抗框架。
Med Image Anal. 2021 May;70:102008. doi: 10.1016/j.media.2021.102008. Epub 2021 Feb 19.
4
Deep learning-based fetoscopic mosaicking for field-of-view expansion.基于深度学习的羊膜镜拼接技术,用于视野扩展。
Int J Comput Assist Radiol Surg. 2020 Nov;15(11):1807-1816. doi: 10.1007/s11548-020-02242-8. Epub 2020 Aug 17.
5
Inter-foetus Membrane Segmentation for TTTS Using Adversarial Networks.利用对抗网络进行 TTTS 的胎儿间膜分割。
Ann Biomed Eng. 2020 Feb;48(2):848-859. doi: 10.1007/s10439-019-02424-9. Epub 2019 Dec 5.
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Retrieval and registration of long-range overlapping frames for scalable mosaicking of in vivo fetoscopy.用于体内胎儿镜可扩展拼接的远程重叠帧的检索和配准。
Int J Comput Assist Radiol Surg. 2018 May;13(5):713-720. doi: 10.1007/s11548-018-1728-4. Epub 2018 Mar 15.
7
Twin-to-twin transfusion syndrome (TTTS).双胎输血综合征(TTTS)。
J Perinat Med. 2011 Mar;39(2):107-12. doi: 10.1515/jpm.2010.147. Epub 2010 Dec 13.
8
The making of fetal surgery.胎儿手术的制作。
Prenat Diagn. 2010 Jul;30(7):653-67. doi: 10.1002/pd.2571.
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Image quality assessment: from error visibility to structural similarity.图像质量评估:从误差可见性到结构相似性。
IEEE Trans Image Process. 2004 Apr;13(4):600-12. doi: 10.1109/tip.2003.819861.