Whorwell P J, Lupton E W, Erduran D, Wilson K
Gut. 1986 Sep;27(9):1014-7. doi: 10.1136/gut.27.9.1014.
Urodynamic studies were carried out on 30 patients with irritable bowel syndrome and 30 matched controls. Fifty per cent of the irritable bowel patients compared with only 13% of the control group had evidence of bladder dysfunction (p = 0.006). In the irritable bowel group detrusor instability was observed in 10 patients compared with only one control subject (p = 0.008). A steep cystometrogram occurred in five irritable bowel patients and three controls (NS). Detrusor instability was most common in patients with a bowel habit characterised by alternating constipation and diarrhoea. This is the first study to provide objective evidence that patients with irritable bowel syndrome may have a disorder of smooth muscle or its innervation that is not confined to the gastrointestinal system.
对30例肠易激综合征患者和30例匹配的对照组进行了尿动力学研究。50%的肠易激综合征患者有膀胱功能障碍的证据，而对照组仅有13%（p = 0.006）。肠易激综合征组有10例患者观察到逼尿肌不稳定，而对照组仅有1例（p = 0.008）。5例肠易激综合征患者和3例对照组出现了陡峭的膀胱压力图（无统计学意义）。逼尿肌不稳定在有便秘和腹泻交替排便习惯的患者中最为常见。这是第一项提供客观证据表明肠易激综合征患者可能存在平滑肌或其神经支配紊乱且不限于胃肠道系统的研究。
