Bayraktar Isık, Cepicka Ladislav, Barasinska Magdalena, Kazan Hasan Huseyin, Zorba Erdal, Ergun Mehmet Ali, Eken Özgür, Ceylan Halil İbrahim, Bulgay Celal, Gabrys Tomasz
Faculty of Sports Sciences, Alanya Alaaddin Keykubat University, Alanya, Türkiye.
Department of Physical Education and Sport, Faculty of Education, University of West Bohemia, Pilsen, Czechia.
Front Psychol. 2023 Jul 31;14:1182575. doi: 10.3389/fpsyg.2023.1182575. eCollection 2023.
Exercise addiction is a phenomenon being able to affecting the athletic performance. The gene, and the polymorphism NM_178510.2:c.2137G > A (rs1800497) has been linked to the exercise addiction. However, further studies on diverse populations and sport branches are needed to totally explore the possible association of this polymorphism with the athletic performance. Thus, the present study aims to decipher any possible relations of the rs1800497 polymorphism with the athletic performance/personal best (PB) and sport experience of elite athletes.
Sixty volunteer elite athletes (31 sprint/power and 29 endurance) and 20 control/sedentary participated in the study. The polymorphism was genotyped using whole exome sequencing approach and PB were determined according to the International Association of Athletics Federations (IAAF) score.
Our results underlined that there were not any significance differences for both allele and genotype frequencies between the groups in terms of athletic performance, although the frequency of allele G was higher ( > 0.05). Nevertheless, sport experience significantly associated with the rs1800496 polymorphism ( < 0.05).
In conclusion, genotype G/G could be inferred to be linked to the higher sport experience and athletic performance. Still, further studies with higher number of participants are needed to conclude the association of this polymorphism with athletic parameters.
运动成瘾是一种能够影响运动表现的现象。基因NM_178510.2:c.2137G > A（rs1800497）的多态性与运动成瘾有关。然而，需要对不同人群和运动项目进行进一步研究，以全面探讨这种多态性与运动表现之间可能存在的关联。因此，本研究旨在解读rs1800497多态性与精英运动员的运动表现/个人最佳成绩（PB）以及运动经历之间的任何可能关系。
60名精英运动员志愿者（31名短跑/力量型和29名耐力型）以及20名对照/久坐者参与了研究。使用全外显子测序方法对多态性进行基因分型，并根据国际田径联合会（IAAF）评分确定PB。
我们的结果强调，尽管等位基因G的频率较高（>0.05），但在运动表现方面，两组之间的等位基因和基因型频率均无显著差异。然而，运动经历与rs1800496多态性显著相关（<0.05）。
总之，可以推断基因型G/G与较高的运动经历和运动表现有关。不过，仍需要更多参与者的进一步研究来确定这种多态性与运动参数之间的关联。
