Department of Neurology, University Hospital of Liège, Liège, Belgium.
Service de Neurologie, CHU de Liège, Avenue de L'Hôpital 1, 4000, Liège, Belgium.
J Neurovirol. 2023 Aug;29(4):507-518. doi: 10.1007/s13365-023-01163-x. Epub 2023 Aug 17.
The coronavirus disease 2019 (COVID-19) can be associated with a wide variety of neurological manifestations. Some of these manifestations might result from the ongoing systemic inflammatory state, but the pathophysiology of specific neurologic involvement is still unclear. In this article, we report a patient who developed an isolated cerebellar syndrome 9 weeks after an episode of COVID-19. The reverse-transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2 was positive on cerebrospinal fluid (CSF). A post-infectious-autoimmune-cerebellitis following COVID-19 was suspected, and the patient was treated with corticosteroids, leading to a complete recovery within a few weeks. We review the other cases of COVID-19-associated cerebellar syndrome reported so far and discuss the potential pathophysiological mechanisms underlying this neurologic manifestation.
新型冠状病毒病 2019（COVID-19）可引起多种神经系统表现。这些表现中的一些可能是由于持续的全身炎症状态引起的，但特定神经受累的病理生理学仍不清楚。在本文中，我们报告了一例 COVID-19 发作后 9 周出现孤立性小脑综合征的患者。COVID-19 后疑诊为感染后自身免疫性小脑炎，给予患者皮质类固醇治疗，数周内完全康复。我们回顾了迄今为止报道的其他 COVID-19 相关小脑综合征病例，并讨论了这种神经系统表现的潜在病理生理学机制。
