Liebman M, Chopin L F, Carter E, Clark A J, Disney G W, Hegsted M, Kenney M A, Kirmani Z A, Koonce K L, Korslund M K
Hypertension. 1986 Oct;8(10):843-50. doi: 10.1161/01.hyp.8.10.843.
Blood pressure levels, anthropometric parameters, and dietary intakes were assessed in 1981 and 1983 in a population of black (n = 236) and white (n = 296) adolescent girls, aged 14 and 16 years in 1983. The 14-year-old black girls exhibited significantly higher mean systolic and diastolic blood pressures than whites in both years. Body weight and Quetelet index were more strongly associated with blood pressure than were height and triceps skinfold thickness. Correcting blood pressures for weight, Quetelet index, 2-year changes in height, and age at menarche decreased in each case (but did not negate) the observed race differences in blood pressure. Dietary calcium and potassium intakes were inversely related to blood pressure, and a race difference in the intake of these nutrients (whites greater than blacks) was observed. Covariate adjustment for calcium, but not for potassium, decreased the magnitude of race differences in blood pressure. Family type (single-parent vs nuclear) and place of residence (urban vs nonurban) appeared to be the most important confounding variables for race differences in blood pressure, since differences largely were eliminated by controlling for these factors. Conflicting reports in the literature regarding the age range during which race differences in blood pressure become apparent may be partially attributed to the complex interrelationships among these factors and the potential influence of other genetic-environmental interactions that may also play a role in blood pressure regulation.
1981年和1983年对1983年年龄为14岁和16岁的236名黑人及296名白人少女进行了血压水平、人体测量参数及饮食摄入量评估。在这两年中,14岁的黑人女孩平均收缩压和舒张压均显著高于白人女孩。与身高和肱三头肌皮褶厚度相比,体重和克托莱指数与血压的关联更为密切。对体重、克托莱指数、身高两年内的变化及初潮年龄进行血压校正后,每种情况下观察到的血压种族差异均减小(但并未消除)。饮食中钙和钾的摄入量与血压呈负相关,且观察到这些营养素摄入量存在种族差异(白人高于黑人)。对钙而非钾进行协变量调整后,血压的种族差异幅度减小。家庭类型(单亲家庭与核心家庭)及居住地点(城市与非城市)似乎是血压种族差异最重要的混杂变量,因为通过控制这些因素,差异基本消除。文献中关于血压种族差异在哪个年龄范围变得明显的报道相互矛盾,这可能部分归因于这些因素之间复杂的相互关系以及其他可能在血压调节中起作用的基因 - 环境相互作用的潜在影响。