Bosserman Rachel E, Farnsworth Christopher W, O'Neil Caroline A, Cass Candice, Park Daniel, Ballman Claire, Wallace Meghan A, Struttmann Emily, Stewart Henry, Arter Olivia, Peacock Kate, Fraser Victoria J, Budge Philip J, Olsen Margaret A, Burnham Carey-Ann D, Babcock Hilary M, Kwon Jennie H
Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
Antimicrob Steward Healthc Epidemiol. 2023 Aug 4;3(1):e133. doi: 10.1017/ash.2022.375. eCollection 2023.
To determine the prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG nucleocapsid (N) antibodies among healthcare personnel (HCP) with no prior history of COVID-19 and to identify factors associated with seropositivity.
Prospective cohort study.
An academic, tertiary-care hospital in St. Louis, Missouri.
The study included 400 HCP aged ≥18 years who potentially worked with coronavirus disease 2019 (COVID-19) patients and had no known history of COVID-19; 309 of these HCP also completed a follow-up visit 70-160 days after enrollment. Enrollment visits took place between September and December 2020. Follow-up visits took place between December 2020 and April 2021.
At each study visit, participants underwent SARS-CoV-2 IgG N-antibody testing using the Abbott SARS-CoV-2 IgG assay and completed a survey providing information about demographics, job characteristics, comorbidities, symptoms, and potential SARS-CoV-2 exposures.
Participants were predominately women (64%) and white (79%), with median age of 34.5 years (interquartile range [IQR], 30-45). Among the 400 HCP, 18 (4.5%) were seropositive for IgG N-antibodies at enrollment. Also, 34 (11.0%) of 309 were seropositive at follow-up. HCP who reported having a household contact with COVID-19 had greater likelihood of seropositivity at both enrollment and at follow-up.
In this cohort of HCP during the first wave of the COVID-19 pandemic, ∼1 in 20 had serological evidence of prior, undocumented SARS-CoV-2 infection at enrollment. Having a household contact with COVID-19 was associated with seropositivity.
确定无新型冠状病毒肺炎（COVID-19）既往病史的医护人员（HCP）中严重急性呼吸综合征冠状病毒2（SARS-CoV-2）IgG核衣壳（N）抗体的流行情况，并确定与血清学阳性相关的因素。
前瞻性队列研究。
密苏里州圣路易斯的一家学术性三级护理医院。
该研究纳入了400名年龄≥18岁、可能接触过2019冠状病毒病（COVID-19）患者且无COVID-19已知病史的医护人员；其中309名医护人员在入组后70-160天还完成了随访。入组访视于2020年9月至1日期间进行。随访访视于2020年12月至2021年4月期间进行。
在每次研究访视时，参与者使用雅培SARS-CoV-2 IgG检测法进行SARS-CoV-2 IgG N抗体检测，并完成一项调查，提供有关人口统计学、工作特征、合并症、症状和潜在SARS-CoV-2暴露的信息。
参与者以女性（64%）和白人（79%）为主，中位年龄为34.5岁（四分位间距[IQR]，30-45）。在400名医护人员中，18名（4.5%）在入组时IgG N抗体血清学呈阳性。此外，309名中的34名（11.0%）在随访时血清学呈阳性。报告有COVID-19家庭接触史的医护人员在入组和随访时血清学呈阳性的可能性更大。
在COVID-19大流行第一波期间的这一医护人员队列中，约20人中有1人在入组时有既往未记录的SARS-CoV-2感染的血清学证据。有COVID-19家庭接触史与血清学阳性相关。
