不同细胞外囊泡亚型在创伤性脑损伤中的作用和治疗潜力。
Roles and therapeutic potential of different extracellular vesicle subtypes on traumatic brain injury.
机构信息
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119, Nansihuan West Road, Fengtai District, Beijing, China.
Beijing Key Laboratory of Central Nervous System Injury, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
出版信息
Cell Commun Signal. 2023 Aug 18;21(1):211. doi: 10.1186/s12964-023-01165-6.
Traumatic brain injury (TBI) is a leading cause of injury-related disability and death around the world, but the clinical stratification, diagnosis, and treatment of complex TBI are limited. Due to their unique properties, extracellular vesicles (EVs) are emerging candidates for being biomarkers of traumatic brain injury as well as serving as potential therapeutic targets. However, the effects of different extracellular vesicle subtypes on the pathophysiology of traumatic brain injury are very different, or potentially even opposite. Before extracellular vesicles can be used as targets for TBI therapy, it is necessary to classify different extracellular vesicle subtypes according to their functions to clarify different strategies for EV-based TBI therapy. The purpose of this review is to discuss contradictory effects of different EV subtypes on TBI, and to propose treatment ideas based on different EV subtypes to maximize their benefits for the recovery of TBI patients. Video Abstract.
创伤性脑损伤（TBI）是全球范围内导致伤害相关残疾和死亡的主要原因，但复杂 TBI 的临床分层、诊断和治疗仍受到限制。由于其独特的性质，细胞外囊泡（EVs）作为创伤性脑损伤的生物标志物以及潜在的治疗靶点的地位不断凸显。然而，不同细胞外囊泡亚型对创伤性脑损伤病理生理学的影响差异很大，甚至可能相反。在细胞外囊泡可被用作 TBI 治疗靶点之前，有必要根据其功能对不同的细胞外囊泡亚型进行分类，以阐明基于 EV 的 TBI 治疗的不同策略。本综述的目的是讨论不同 EV 亚型对 TBI 的矛盾作用，并根据不同的 EV 亚型提出治疗思路，以最大限度地发挥其对 TBI 患者康复的益处。视频摘要。
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