Lin Mao-Hsun, Lee Chun-Ying, Chuang Yun-Shiuan, Shih Chia-Lung
Division of Neurology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, Taiwan.
Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Environ Res. 2023 Nov 15;237(Pt 1):116900. doi: 10.1016/j.envres.2023.116900. Epub 2023 Aug 18.
Bisphenol A (BPA), a toxic endocrine disruptor, is widely distributed in the environment, and the effects of BPA exposure on human health outcomes are a critical issue. The objective of this study was to perform an umbrella review of published meta-analyses investigating the associations between BPA exposure and human-related health outcomes. The relevant reports were searched from three electronic databases from inception to July 12, 2023 including PubMed, ScienceDirect, and Embase. The reports that were systematic reviews with meta-analyses investigating the associations between BPA exposure and human health outcomes were included in our review. A total of 14 reports were included in our review. Several human health outcomes related to exposure BPA were investigated including maternal prenatal health, infant health, allergic diseases, kidney disease, metabolic syndromes, polycystic ovary syndrome, earlier puberty, inflammation and immune responses, and thyroid function in neonates. Among these health outcomes, BPA exposure was associated with multiple human health outcomes including preterm birth, allergic diseases, kidney disease, polycystic ovarian syndrome, obesity, type 2 diabetes, cardiovascular disease, hypertension, and inflammation and immune responses (C-reactive protein and interleukin-6). These results showed that BPA exposure has seriously affected human health. To protect human health, World Health Organization should develop meaningful regulations on BPA to decrease the environmental contamination.
双酚A（BPA）是一种有毒的内分泌干扰物，广泛分布于环境中，BPA暴露对人类健康结果的影响是一个关键问题。本研究的目的是对已发表的荟萃分析进行一项综合评价，以调查BPA暴露与人类相关健康结果之间的关联。从三个电子数据库（从创建到2023年7月12日，包括PubMed、ScienceDirect和Embase）中检索相关报告。纳入我们综述的报告是对BPA暴露与人类健康结果之间关联进行调查的系统评价和荟萃分析。我们的综述共纳入了14份报告。研究了与BPA暴露相关的几种人类健康结果，包括孕产妇产前健康、婴儿健康、过敏性疾病、肾脏疾病、代谢综合征、多囊卵巢综合征、青春期提前、炎症和免疫反应以及新生儿甲状腺功能。在这些健康结果中，BPA暴露与多种人类健康结果相关，包括早产、过敏性疾病、肾脏疾病、多囊卵巢综合征、肥胖、2型糖尿病、心血管疾病、高血压以及炎症和免疫反应（C反应蛋白和白细胞介素-6）。这些结果表明，BPA暴露严重影响了人类健康。为了保护人类健康，世界卫生组织应制定有关BPA的有意义的法规，以减少环境污染。
