Mathonat Estelle, Canceill Thibault, Marty Mathieu, Prosper Alison, Vinel Alexia, Noirrit-Esclassan Emmanuelle
Odontology Department, Health Faculty, Toulouse University, 3 Chemin des Maraichers, 31400 Toulouse, France.
Odontology and Oral Medicine Department, Toulouse Universitary Hospital, 2 rue de Viguerie, 31100 Toulouse, France.
Dent J (Basel). 2025 Jul 22;13(8):332. doi: 10.3390/dj13080332.
: This study aimed to assess, through a systematic review, the potential link between bisphenol A (BPA) exposure and molar incisor hypomineralization (MIH). : A systematic review was performed according to the PRISMA grid. All international studies-in vitro, in vivo, or clinical-evaluating the relationships between bisphenol A and MIH were included. An iterative search of eligible publications was conducted on May 26, 2025, using three different databases: PubMed, Science Direct, and Google Scholar. : Eleven studies were included in the review, ten of which were experimental studies. They were published between 2013 and 2024. Among the selected articles, a rat model was used in eight studies and seven established a link between MIH and BPA (63.64% of the articles). In the included studies, the incisors of rats treated with BPA presented asymmetrical white spots at the enamel level, with a phenotype similar to human MIH. The authors highlight the hypothesis of the implication of steroid receptors expressed by ameloblasts, in particular at the stage of maturation, thus impacting enamel quality. : The results presented in this review highlight a trend in the interaction of bisphenol A with steroid receptors, thus affecting enamel quality. However, these associations are weak, and future studies should investigate cofactors modulating BPA's role in the development of MIH.
本研究旨在通过系统评价评估双酚A（BPA）暴露与磨牙切牙矿化不全（MIH）之间的潜在联系。
根据PRISMA流程进行系统评价。纳入所有评估双酚A与MIH之间关系的国际研究——体外、体内或临床研究。于2025年5月26日使用三个不同的数据库（PubMed、ScienceDirect和谷歌学术）对符合条件的出版物进行迭代检索。
该评价纳入了11项研究，其中10项为实验研究。这些研究发表于2013年至2024年之间。在所选文章中，8项研究使用了大鼠模型，7项研究建立了MIH与BPA之间的联系（占文章的63.64%）。在纳入的研究中，用BPA处理的大鼠切牙在釉质水平出现不对称白斑，其表型与人类MIH相似。作者强调了成釉细胞表达的类固醇受体的作用假说，特别是在成熟阶段，从而影响釉质质量。
本评价呈现的结果突出了双酚A与类固醇受体相互作用的一种趋势，从而影响釉质质量。然而，这些关联较弱，未来的研究应调查调节BPA在MIH发生中作用的辅助因素。
