Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO-Public Health), Av. Catalunya 21, 46020, Valencia, Spain; Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Av. Sos Baynat S/N, 12071, Castelló de la Plana, Spain.
Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO-Public Health), Av. Catalunya 21, 46020, Valencia, Spain.
Chemosphere. 2023 Nov;340:139879. doi: 10.1016/j.chemosphere.2023.139879. Epub 2023 Aug 18.
In this work, an analytical strategy based on non-target screening of semi-volatile organic compounds and subsequent risk assessment for adult and child populations has been conducted for the first time in household indoor dust samples in Spain. The methodology was based on a microwave-assisted extraction followed by gas chromatography coupled to high resolution mass spectrometry determination, using a hybrid quadrupole-orbitrap analyzer. The procedure was applied to 19 residential indoor dust samples, collected in different Spanish regions (namely Galicia, La Rioja, Catalunya, the Balearic Islands, and the Valencian Region). From the generated data, 4067 features were obtained, of which 474 compounds were tentatively identified with a high level of identification confidence (probable structure by library spectrum match or confirmed by reference standard), using a restrictive set of identification criteria. Most of the identified chemicals were natural products, metabolites, additives, and substances with industrial applications in the field of foods, cosmetics, pharmaceuticals, pesticides, and plastics. Finally, risk assessment was carried out by applying the threshold of toxicological concern approach, showing that risk to adult and child populations associated with the presence of the identified substances in the indoor dust was not expected, although the existence of indoor environments with conditions of potential risk cannot be discarded under a worst-case scenario approach.
本研究首次在西班牙家庭室内灰尘样本中采用基于半挥发性有机化合物非靶向筛选和随后进行成人及儿童群体风险评估的分析策略。该方法基于微波辅助提取，随后使用混合四极杆轨道阱分析仪进行气相色谱 - 高分辨率质谱测定。该程序应用于 19 个居住室内灰尘样本，采集于西班牙不同地区（加利西亚、拉里奥哈、加泰罗尼亚、巴利阿里群岛和瓦伦西亚地区）。从生成的数据中，获得了 4067 个特征，其中 474 种化合物通过库谱匹配的可能性结构或通过参考标准得到确认，具有较高的鉴定置信度（鉴定标准），使用了一组限制性的鉴定标准。大多数鉴定出的化学物质为天然产物、代谢物、添加剂和具有食品、化妆品、制药、农药和塑料等领域工业应用的物质。最后，通过应用毒理学关注阈值方法进行风险评估，结果表明，室内灰尘中存在的已鉴定物质对成人和儿童群体的风险预计不会产生影响，但在最坏情况假设下，不能排除存在具有潜在风险条件的室内环境。
