TaghipourZahri Shokouh, Derakhshani Fatemeh, Vahidy Mohammad Reza, Meybodian Mojtaba
Department of Pathology, Shahid Sadoughi University of Medical Sciences and Health Services, Shahid Sadoughi General Hospital, Yazd, Iran.
Shahid Sadoughi University of Medical sciences and Health Services, Shahid Sadoughi General Hospital, Yazd, Iran.
Iran J Pathol. 2023 Spring;18(2):225-228. doi: 10.30699/IJP.2023.1971484.2998. Epub 2023 Jun 20.
Angiosarcoma is a malignant vascular tumor that occurs mostly in the soft tissues, skin, trunk, and limbs. Angiosarcoma of the parotid gland is a very uncommon and rare tumor. Herein, we presented a case of a 66-year-old man who was referred for a lump in his neck and his initial biopsy reported Castleman disease. After three months during which the mass did not resolve, a re-biopsy was performed. The biopsy revealed vascular neoplasm composed of neoplastic spindle cells arranged in fascicles with extravasation of the red blood cells within the lymph node. A diagnosis of metastatic angiosarcoma was confirmed by immunohistochemical staining. The neoplastic cells were positive for vimentin, EMA, and CD31. The patient underwent radiation therapy. Nine months later, MRI (magnetic resonance imaging) showed a tumor in the parotid gland. The microscopic examination revealed a primary angiosarcoma of the parotid. Although primary angiosarcoma of the parotid gland is very rare, it should be considered as a possible origin in metastatic angiosarcoma of the neck. Further studies are recommended to more cleary define the process.
血管肉瘤是一种恶性血管肿瘤，主要发生于软组织、皮肤、躯干和四肢。腮腺血管肉瘤是一种非常罕见的肿瘤。在此，我们报告一例66岁男性，因颈部肿块前来就诊，其初次活检报告为Castleman病。三个月后肿块未消退，遂进行再次活检。活检显示为血管性肿瘤，由呈束状排列的肿瘤性梭形细胞组成，淋巴结内有红细胞外渗。免疫组化染色确诊为转移性血管肉瘤。肿瘤细胞波形蛋白、上皮膜抗原（EMA）和CD31呈阳性。患者接受了放射治疗。九个月后，磁共振成像（MRI）显示腮腺有肿瘤。显微镜检查显示为腮腺原发性血管肉瘤。虽然腮腺原发性血管肉瘤非常罕见，但在颈部转移性血管肉瘤中应考虑其可能的起源。建议进一步研究以更清楚地界定这一过程。
