Zhan Chuan-Hua, Liu Guo-Jun
Department of Clinical Laboratory, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, People's Republic of China.
Department of Breast Cancer Surgery, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, People's Republic of China.
Breast Cancer (Dove Med Press). 2023 Aug 15;15:617-623. doi: 10.2147/BCTT.S410500. eCollection 2023.
To investigate the diagnostic value of the combined detection of α-hydroxybutyrate dehydrogenase (α-HBDH), carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125) in early-stage breast cancer (ESBC).
This was a retrospective analysis of 169 patients with ESBC, 138 patients with benign breast disease (BBD) and 200 normal healthy controls (NHCs). The levels of serum α-HBDH, CEA and CA125 in the two groups were detected. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to analyse the diagnostic value of the above indicators alone and in combination for ESBC.
The levels of α-HBDH, CEA and CA125 in the ESBC group were significantly higher than those in the BBD and NHC groups ([118.18 ± 11.19 vs 91.24 ± 9.17 vs 89.38 ± 9.01, = 6.189, = 0.004], [2.39 ± 1.12 vs 1.48 ± 0.76 vs 1.58 ± 0.58, = 5.362, = 0.017] and [14.44 ± 6.78 vs 11.19 ± 3.17 vs 7.18 ± 4.71, = 8.912, = 0.001], respectively). In the ESBC group, the positive rate of combined detection was higher than that of single detection (96.12% vs 72.64% vs 53.67% vs 42.41%, X = 27.174, < 0.05). ROC curve analysis showed that serum α-HBDH, CEA, CA125 alone and combined detection in the diagnosis of ESBC. The sensitivity was 48.1%, 63.6%, 44.2% and 54.5%, the specificity was 75.4%, 75.4%, 86.0% and 91.2% and the AUC was 0.654, 0.715, 0.636 and 0.772, respectively. The diagnostic value of combined detection was the highest.
The levels of serum α-HBDH, CEA and CA125 in ESBC are high, and the combined detection of the three has a high diagnostic value for ESBC.
探讨联合检测α-羟丁酸脱氢酶（α-HBDH）、癌胚抗原（CEA）和癌抗原125（CA125）在早期乳腺癌（ESBC）中的诊断价值。
对169例ESBC患者、138例乳腺良性疾病（BBD）患者和200例正常健康对照者（NHC）进行回顾性分析。检测两组患者血清α-HBDH、CEA和CA125水平。采用受试者工作特征（ROC）曲线及曲线下面积（AUC）分析上述指标单独及联合检测对ESBC的诊断价值。
ESBC组α-HBDH、CEA和CA125水平显著高于BBD组和NHC组（[118.18±11.19 vs 91.24±9.17 vs 89.38±9.01，F=6.189，P=0.004]，[2.39±1.12 vs 1.48±0.76 vs 1.58±0.58，F=5.362，P=0.017]及[14.44±6.78 vs 11.19±3.17 vs 7.18±4.71，F=8.912，P=0.001]）。在ESBC组中，联合检测的阳性率高于单项检测（96.12% vs 72.64% vs 53.67% vs 42.41%，χ²=27.174，P<0.05）。ROC曲线分析显示，血清α-HBDH、CEA、CA125单独及联合检测对ESBC均有诊断价值。其灵敏度分别为48.1%、63.6%、44.2%和54.5%，特异度分别为75.4%、75.4%、86.0%和91.2%，AUC分别为0.654、0.715、0.636和0.772。联合检测的诊断价值最高。
ESBC患者血清α-HBDH、CEA和CA125水平升高，三者联合检测对ESBC具有较高的诊断价值。
