Marjańska Małgorzata, Teisseyre Thomas Z, Halpern-Manners Nicholas W, Zhang Yi, Iltis Isabelle, Bajaj Vikram, Ugurbil Kamil, Pines Alexander, Henry Pierre-Gilles
Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, 2021 6 ST SE, Minneapolis, Minnesota 55455, United States.
Department of Chemistry, University of California at Berkeley, Berkeley, California 94720, United States.
Appl Magn Reson. 2012 Jul;43(1-2):289-297. doi: 10.1007/s00723-012-0348-3. Epub 2012 May 20.
Recently, hyperpolarized substrates generated through dynamic nuclear polarization have been introduced to study metabolism. Injection of hyperpolarized [1-C]pyruvate, the most widely used substrate, allows detection of time courses of [1-C]pyruvate and its metabolic products, such as [1-C]lactate and C-bicarbonate, in various organs. However, quantitative metabolic modeling of data to measure specific metabolic rates remains challenging without measuring the input function. In this study, we demonstrate that the input function of [1-C]pyruvate can be measured in the rat carotid artery using an implantable coil.
最近，通过动态核极化产生的超极化底物已被引入用于研究代谢。注射最广泛使用的底物超极化[1-C]丙酮酸，能够检测[1-C]丙酮酸及其代谢产物（如[1-C]乳酸和C-碳酸氢盐）在各个器官中的时间进程。然而，在不测量输入函数的情况下，对数据进行定量代谢建模以测量特定代谢率仍然具有挑战性。在本研究中，我们证明了使用可植入线圈可以在大鼠颈动脉中测量[1-C]丙酮酸的输入函数。
