MOTIVATION: Augmented reality head-up display (AR-HUD) interface design takes on critical significance in enhancing driving safety and user experience among professional drivers. However, optimizing the above-mentioned interfaces poses challenges, innovative methods are urgently required to enhance performance and reduce cognitive load. DESCRIPTION: A novel method was proposed, combining the IVPM method with a GA to optimize AR-HUD interfaces. Leveraging machine learning, the IVPM-GA method was adopted to predict cognitive load and iteratively optimize the interface design. RESULTS: Experimental results confirmed the superiority of IVPM-GA over the conventional BP-GA method. Optimized AR-HUD interfaces using IVPM-GA significantly enhanced the driving performance, and user experience was enhanced since 80% of participants rated the IVPM-GA interface as visually comfortable and less distracting. CONCLUSION: In this study, an innovative method was presented to optimize AR-HUD interfaces by integrating IVPM with a GA. IVPM-GA effectively reduced cognitive load, enhanced driving performance, and improved user experience for professional drivers. The above-described findings stress the significance of using machine learning and optimization techniques in AR-HUD interface design, with the aim of enhancing driver safety and occupational health. The study confirmed the practical implications of machine learning optimization algorithms for designing AR-HUD interfaces with reduced cognitive load and improved occupational safety and health (OSH) for professional drivers.