Gargori Nezar M B, Alahwal Hazem, Vacheron Charles-Herve, Alam Farouq Mohammad A
Department of Anesthesia and Intensive Care, Faculty of Medicine, Abdulaziz University, Jeddah, Western Region, Kingdom of Saudi Arabia.
Hospices Civils de Lyon, Lyon, Auverange Rhone Alpes, France.
Saudi J Anaesth. 2023 Jul-Sep;17(3):340-348. doi: 10.4103/sja.sja_737_22. Epub 2023 Jun 22.
Intravenous (IV) ketamine is used for chronic neuropathic pain refractory to other treatments. Administration of such a medication requires high-cost services while the result is not always satisfactory with a significant percentage of failure. Success and failure are related to some factors.
In this study, we aim to point the most responsive disease category to IV ketamine and the predictive factors for successful and failed treatment. Two hundred and sixty-nine patients out of 371 were included. Demographic, clinical, and therapy-related variables were retrospectively collected and then statistically analyzed using various descriptive and inferential methods. A few descriptive statistics are obtained for the variables depending on their nature (e.g., percentages for qualitative variables and means for quantitative variables). Furthermore, several inferential methods are considered to address some statistical points of interest, including, but not limited to, odds ratio interpretations via logistic regression as well as association and correlation analyses.
A significant association was found between the presence of intermittent pain pattern as well as the pain of chronic primary category and favorable response to IV ketamine while the history of previous analgesic interventions was significantly associated with a negative response.
The identified factors can be used to prospectively study the efficacy of ketamine using selection criteria based on the observed results in our study to re-evaluate the percentage of responsiveness according to these new parameters.
静脉注射氯胺酮用于治疗对其他治疗无效的慢性神经性疼痛。使用这种药物需要高昂的医疗服务成本，而且治疗结果并不总是令人满意，失败率相当高。治疗的成功与失败与一些因素有关。
在本研究中，我们旨在指出对静脉注射氯胺酮反应最敏感的疾病类别以及治疗成功与失败的预测因素。从371名患者中纳入了269名。回顾性收集人口统计学、临床和治疗相关变量，然后使用各种描述性和推断性方法进行统计分析。根据变量的性质获得一些描述性统计量（例如，定性变量的百分比和定量变量的均值）。此外，考虑了几种推断性方法来解决一些感兴趣的统计问题，包括但不限于通过逻辑回归进行比值比解释以及关联和相关性分析。
发现间歇性疼痛模式以及慢性原发性疼痛的存在与对静脉注射氯胺酮的良好反应之间存在显著关联，而既往镇痛干预史与负面反应显著相关。
根据我们研究中观察到的结果，所确定的因素可用于前瞻性研究氯胺酮的疗效，使用选择标准重新评估根据这些新参数的反应率。
