骨科感染中的胶原绒。
Collagen fleece in orthopaedic infections.
作者信息
Ge Susan M, Harvey Edward J
机构信息
McGill University, Dept of Surgery, Division of Orthopedic Surgery, Montreal Quebec Canada.
出版信息
OTA Int. 2021 Jun 15;4(3 Suppl). doi: 10.1097/OI9.0000000000000111. eCollection 2021 Jun.
Abstract
Collagen fleece is a relatively new development. It represents another option in the battle against infection. It is a cheap, biocompatible, and resorbable local antibiotic delivery mechanism with favorable drug release kinetics and low risk of adverse effects or toxicity. Benefit may be conferred when used in contaminated cases. Significantly more research is still needed before the adoption of collagen fleece as the standard of care. However, we can likely conclude that there are no major adverse effects and it can be safely used as an adjunct in addition to conventional therapies for the prophylaxis and treatment of infections.
摘要
胶原纤维网是一项相对较新的进展。它是对抗感染的另一种选择。它是一种廉价、生物相容性好且可吸收的局部抗生素递送机制，具有良好的药物释放动力学，且不良反应或毒性风险低。在污染病例中使用可能有益。在将胶原纤维网作为标准治疗方法采用之前，仍需要进行更多的研究。然而，我们可以大概率得出结论，即它没有重大不良反应，并且除了用于预防和治疗感染的传统疗法之外，它还可以安全地用作辅助手段。
相似文献
1
Collagen fleece in orthopaedic infections.骨科感染中的胶原绒。
OTA Int. 2021 Jun 15;4(3 Suppl). doi: 10.1097/OI9.0000000000000111. eCollection 2021 Jun.
2
Elution kinetics, antimicrobial efficacy, and degradation and microvasculature of a new gentamicin-loaded collagen fleece.一种新型载庆大霉素胶原绒的洗脱动力学、抗菌效果以及降解与微血管情况
J Biomed Mater Res B Appl Biomater. 2009 Jul;90(1):210-22. doi: 10.1002/jbm.b.31275.
3
Understanding osteomyelitis and its treatment through local drug delivery system.了解骨髓炎及其通过局部药物输送系统的治疗。
Biotechnol Adv. 2016 Dec;34(8):1305-1317. doi: 10.1016/j.biotechadv.2016.09.005. Epub 2016 Sep 28.
4
Biodegradable antibiotic delivery systems.可生物降解的抗生素递送系统。
J Bone Joint Surg Br. 2011 Feb;93(2):151-7. doi: 10.1302/0301-620X.93B2.24933.
5
Improvement of perineal wound healing by local administration of gentamicin-impregnated collagen fleeces after abdominoperineal excision of rectal cancer.直肠癌腹会阴联合切除术后局部应用庆大霉素浸渍胶原绒促进会阴伤口愈合
Am J Surg. 2001 Nov;182(5):502-9. doi: 10.1016/s0002-9610(01)00762-0.
6
Local application of gentamicin-containing collagen implant in the prophylaxis and treatment of surgical site infection in orthopaedic surgery.局部应用庆大霉素胶原植入物预防和治疗骨科手术部位感染。
Int J Surg. 2012;10 Suppl 1:S15-20. doi: 10.1016/j.ijsu.2012.05.020. Epub 2012 May 30.
7
Diagnosis and treatment of diabetic foot infections.糖尿病足感染的诊断与治疗
Plast Reconstr Surg. 2006 Jun;117(7 Suppl):212S-238S. doi: 10.1097/01.prs.0000222737.09322.77.
8
Biomaterials approaches to treating implant-associated osteomyelitis.治疗植入物相关骨髓炎的生物材料方法。
Biomaterials. 2016 Mar;81:58-71. doi: 10.1016/j.biomaterials.2015.12.012. Epub 2015 Dec 18.
9
Combining local antibiotic delivery with heparinized nanohydroxyapatite/collagen bone substitute: A novel strategy for osteomyelitis treatment.将局部抗生素递送与肝素化纳米羟基磷灰石/胶原蛋白骨替代物相结合：一种治疗骨髓炎的新策略。
Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111329. doi: 10.1016/j.msec.2020.111329. Epub 2020 Aug 7.
10
Mid- to long-term results of single-stage surgery for patients with chronic osteomyelitis using a bioabsorbable gentamicin-loaded ceramic carrier.使用载有庆大霉素的可吸收陶瓷载体进行一期手术治疗慢性骨髓炎的中远期疗效。
Bone Joint J. 2022 Sep;104-B(9):1095-1100. doi: 10.1302/0301-620X.104B9.BJJ-2022-0396.R1.
本文引用的文献
1
General treatment principles for fracture-related infection: recommendations from an international expert group.骨折相关感染的一般治疗原则：国际专家组的建议。
Arch Orthop Trauma Surg. 2020 Aug;140(8):1013-1027. doi: 10.1007/s00402-019-03287-4. Epub 2019 Oct 29.
2
Evidence-Based Recommendations for Local Antimicrobial Strategies and Dead Space Management in Fracture-Related Infection.骨折相关感染局部抗菌策略和无效腔管理的循证推荐
J Orthop Trauma. 2020 Jan;34(1):18-29. doi: 10.1097/BOT.0000000000001615.
3
Clinical practice in prevention of fracture-related infection: An international survey among 1197 orthopaedic trauma surgeons.预防骨折相关感染的临床实践：1197 名创伤骨科医师的国际调查。
Injury. 2019 Jun;50(6):1208-1215. doi: 10.1016/j.injury.2019.04.013. Epub 2019 Apr 21.
4
The effect of local antibiotic prophylaxis when treating open limb fractures: A systematic review and meta-analysis.局部抗生素预防在治疗开放性四肢骨折时的效果：一项系统评价与荟萃分析。
Bone Joint Res. 2018 Aug 4;7(7):447-456. doi: 10.1302/2046-3758.77.BJR-2018-0043.R1. eCollection 2018 Jul.
5
A survey of practice and opinions on the use of topical antibiotics to prevent surgical site infection: more confusion than consensus.一项关于预防手术部位感染使用局部抗生素的实践和意见的调查：共识多于混乱。
J Antimicrob Chemother. 2018 Jul 1;73(7):1978-1983. doi: 10.1093/jac/dky097.
6
Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton.
Ann Agric Environ Med. 2017 May 11;24(2):299-302. doi: 10.5604/12321966.1235182.
7
Fast-resorbable antibiotic-loaded hydrogel coating to reduce post-surgical infection after internal osteosynthesis: a multicenter randomized controlled trial.可快速吸收的载抗生素水凝胶涂层减少内固定术后手术部位感染：一项多中心随机对照试验
J Orthop Traumatol. 2017 Jun;18(2):159-169. doi: 10.1007/s10195-017-0442-2. Epub 2017 Feb 2.
8
Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections - A Multinational Study.用于慢性骨感染的抗菌生物活性玻璃S53P4——一项多国研究
Adv Exp Med Biol. 2017;971:81-92. doi: 10.1007/5584_2016_156.
9
Clinical Application of Antimicrobial Bone Graft Substitute in Osteomyelitis Treatment: A Systematic Review of Different Bone Graft Substitutes Available in Clinical Treatment of Osteomyelitis.抗菌骨移植替代物在骨髓炎治疗中的临床应用：对骨髓炎临床治疗中可用的不同骨移植替代物的系统评价
Biomed Res Int. 2016;2016:6984656. doi: 10.1155/2016/6984656. Epub 2016 Jan 21.
10
Biofilm Antimicrobial Susceptibility Increases With Antimicrobial Exposure Time.生物膜对抗菌药物的敏感性随抗菌药物暴露时间的增加而增强。
Clin Orthop Relat Res. 2016 Jul;474(7):1659-64. doi: 10.1007/s11999-016-4700-z.
Zotero 插件