Basic Science Center Project of National Natural Science Foundation of China, Key Laboratory for Ultrafine Materials of Ministry of Education, and School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, 200237, Shanghai, P. R. China.
Adv Healthc Mater. 2023 Jul;12(18):e2300475. doi: 10.1002/adhm.202300475. Epub 2023 Mar 17.
On-skin personal electrocardiography (ECG) devices, which can monitor real-time cardiac autonomic changes, have been widely applied to predict cardiac diseases and save lives. However, current interface electrodes fail to be unconditionally and universally applicable, often losing their efficiency and functionality under harsh atmospheric conditions (e.g., underwater, abnormal temperature, and humidity). Herein, an environmentally adaptable organo-ionic gel-based electrode (OIGE) is developed with a facile one-pot synthesis of highly conductive choline-based ionic liquid ([DMAEA-Q] [TFSI], I.L.) and monomers (2,2,2-trifluoroethyl acrylate (TFEA) and N-hydroxyethyl acrylamide (HEAA). In virtue of inherent conductivity, self-responsive hydrophobic barriers, dual-solvent effect, and multiple interfacial interactions, this OIGE features distinct sweat and water-resistance, anti-freezing and anti-dehydration properties with strong adhesiveness and electrical stability under all kinds of circumstances. In contrast to the dysfunction of commercial gel electrodes (CGEs), this OIGE with stronger adhesion as well as skin tolerability can realize a real-time and accurate collection of ECG signals under multiple extreme conditions, including aquatic environments (sweat and underwater), cryogenic (<-20°C) and arid (dehydration) environments. Therefore, the OIGE shows great prospects in diagnosing cardiovascular diseases and paves new horizons for multi-harsh environmental personalized healthcare.
基于有机离子凝胶的可适应环境的电极用于在各种极端条件下实时、准确地采集心电图信号
可在皮肤上使用的个人心电图 (ECG) 设备可以实时监测心脏自主变化，已被广泛用于预测心脏疾病和挽救生命。然而，当前的接口电极无法无条件地普遍适用，在恶劣的大气条件下（例如水下、异常温度和湿度）经常会失去其效率和功能。在此，通过胆碱基离子液体 ([DMAEA-Q] [TFSI]，I.L.) 和单体（2,2,2-三氟乙基丙烯酸酯 (TFEA) 和 N-羟乙基丙烯酰胺 (HEAA) 的简便一锅合成，开发了一种环境适应性的有机离子凝胶基电极 (OIGE)。由于固有导电性、自响应疏水性屏障、双溶剂效应和多种界面相互作用，这种 OIGE 具有明显的耐汗和耐水性、抗冻和抗脱水特性，在各种情况下都具有很强的粘附力和电稳定性。与商业凝胶电极 (CGEs) 的功能障碍相比，这种具有更强粘附力和皮肤耐受性的 OIGE 可以在包括水下环境（汗液和水下）、低温 (<-20°C) 和干旱（脱水）环境在内的多种极端条件下实现实时、准确地采集 ECG 信号。因此，OIGE 在诊断心血管疾病方面具有广阔的前景，为多恶劣环境下的个性化医疗保健开辟了新的途径。
