八角茴香对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用。
Antidiabetic Effect of Star Anise () in Streptozotocin-induced Diabetic Rats.
作者信息
Amtaghri Smail, Qabouche Adil, Slaoui Miloudia, Eddouks Mohamed
机构信息
Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia, 52000, Morocco.
Energy, Materials and Sustainable Development (EMDD) Team- Higher School of Technology-SALE, Center for Water, Natural Resources Environment and Sustainable Development (CERNE2D), Mohammed V University in Rabat, Rabat, Morocco.
出版信息
Cardiovasc Hematol Disord Drug Targets. 2023;23(2):92-98. doi: 10.2174/1871529X23666230823112113.
AIM
The current study aimed to evaluate the antidiabetic potential of Illicium verum fruits.
BACKGROUND
Illicium verum fruits are frequently used by the Moroccan population in the treatment of diabetes.
METHODS
The antihyperglycemic effect of the aqueous extract of Illicium verum fruits (AEIVF) in rats was assessed. The effects of AEIVF (20 mg/kg) on glycemia and lipid profile as well as its phytochemical and antioxidant properties were evaluated.
RESULTS
In normal and diabetic rats, AEIVF reduced blood glucose levels 6 hours after administration. Furthermore, after 7 days of treatment, glycemia was lowered in diabetic rats, and this extract exhibited an antioxidant activity.
CONCLUSION
The study shows that Illicium verum possesses a potent antidiabetic activity. In addition, the toxicity of AEIVF was evaluated and the LD value was found to be greater than the 2 g/kg dose.
目的
本研究旨在评估八角茴香果实的抗糖尿病潜力。
背景
摩洛哥人群经常使用八角茴香果实治疗糖尿病。
方法
评估八角茴香果实水提取物（AEIVF）对大鼠的降血糖作用。评价了AEIVF（20mg/kg）对血糖和血脂谱的影响及其植物化学和抗氧化特性。
结果
在正常和糖尿病大鼠中，AEIVF给药6小时后可降低血糖水平。此外，治疗7天后，糖尿病大鼠的血糖降低，且该提取物表现出抗氧化活性。
结论
该研究表明八角茴香具有强大的抗糖尿病活性。此外，还评估了AEIVF的毒性，发现其半数致死量值大于2g/kg剂量。
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