在链脲佐菌素诱导的糖尿病大鼠中， 的降血糖、降血脂和抗氧化作用。
Antihyperglycemic, Antihyperlipidemic, and Antioxidant Effects of in Streptozotocin-Induced Diabetic Rats.
机构信息
Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia 52000, Morocco.
出版信息
Cardiovasc Hematol Disord Drug Targets. 2022;22(2):118-127. doi: 10.2174/1871529X22666220806122012.
AIMS
The study aimed to assess the antidiabetic effect of Salvia tingitana (S. tingitana).
BACKGROUND
S. tingitana is an aromatic plant that belongs to the Lamiaceae family. Phytochemical analysis of the aerial parts of S. tingitana revealed the existence of terpenoids and flavonoids. In addition, S. tingitana possesses antimicrobial activity.
OBJECTIVE
The goal of the study was to obtain information about the antihyperglycemic, antihyperlipidemic, antioxidant abilities of S. tingitana aqueous extract.
METHODS
The effect of an acute and sub-chronic administration of S. tingitana aqueous extract (AEST) at the doses of 60 and 80 mg/kg on glucose, lipid profile, and lipoprotein profile was examined in normoglycemic and hyperglycemic rats. Additionally, a preliminary phytochemical screening and the antioxidant activity using DPPH assay were carried out.
RESULTS
Rats treated with AEST at a dose of 60 mg/kg showed a significant decrease in the serum glucose levels during the single oral administration at the 4th and 6th hour of treatment in both normal and streptozotocin(STZ)-induced hyperglycemic rats. Interestingly, a dose of 80 mg/kg AEST produced a significant lowering effect on blood glucose levels at the 2nd, 4th, and 6th hour of treatment after a single oral administration in both diabetic and normal rats. Both doses of AEST (60 and 80 mg/kg) revealed a significant amelioration of lipid and lipoprotein profile. In addition, the qualitative and quantitative phytochemical analysis proved the presence of polyphenols compounds, flavonoids, and tannins. Results suggest that S. tingitana contains some secondary metabolites like alkaloids, phenols, flavonoids, and saponins. Importantly, the study revealed that the aqueous extract of S. tingitana has a very interesting antioxidant activity (IC50 = 553.21 μg/ml).
CONCLUSION
The study illustrates the beneficial action of the aqueous extract of S. tingitana as an antihyperglycemic and antihyperlipidemic agent.
目的
本研究旨在评估丹参（S. tingitana）的降血糖作用。
背景
丹参是唇形科的一种芳香植物，其地上部分的植物化学分析表明存在萜类化合物和类黄酮。此外，丹参具有抗菌活性。
目的
本研究的目的是了解丹参水提物的降血糖、降血脂、抗氧化能力。
方法
在正常血糖和高血糖大鼠中，分别给予 60 和 80mg/kg 剂量的丹参水提物（AEST）的急性和亚慢性给药，检测其对血糖、血脂谱和脂蛋白谱的影响。此外，还进行了初步的植物化学筛选和使用 DPPH 测定法测定抗氧化活性。
结果
AEST 剂量为 60mg/kg 的大鼠在单次口服给药后第 4 和第 6 小时，在正常和链脲佐菌素（STZ）诱导的高血糖大鼠中，血清葡萄糖水平显著降低。有趣的是，AEST 剂量为 80mg/kg 时，在单次口服给药后第 2、4 和 6 小时，对糖尿病和正常大鼠的血糖水平均有显著降低作用。AEST 的两种剂量（60 和 80mg/kg）均显著改善了血脂和脂蛋白谱。此外，定性和定量的植物化学分析证明了多酚化合物、类黄酮和单宁的存在。结果表明，丹参含有一些次生代谢物，如生物碱、酚类、类黄酮和皂苷。重要的是，该研究表明，丹参的水提物具有非常有趣的抗氧化活性（IC50=553.21μg/ml）。
结论
本研究表明丹参水提物具有降血糖和降血脂作用。
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