沙哈拉蜂胶对链脲佐菌素诱导的糖尿病大鼠糖代谢的有益影响。
Beneficial Effect of Saharan Propolis on Glucose Metabolism in Streptozotocin- induced Diabetic Rats.
机构信息
Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, 52000, Errachidia,,Morocco.
出版信息
Cardiovasc Hematol Disord Drug Targets. 2021;21(4):243-252. doi: 10.2174/1871529X21666211118141935.
AIMS
The aim of the study was to evaluate the antihyperglycemic activity of propolis from Saharan region of Morocco.
BACKGROUND
Propolis is known from ancient times for its beneficial action on health.
OBJECTIVE
The study aimed to evaluate the effect of Moroccan propolis aqueous extract from the desert region on glycemia and lipid metabolism.
METHODS
The antihyperglycemic and antidyslipidemic activities of Moroccan propolis aqueous extract were evaluated in streptozotocin-induced diabetic rats. Glycemia was monitored during acute (6h) and subchronic treatments. Histopathological analysis of the liver and the serum lipid profile was also evaluated in addition to the glucose tolerance.
RESULTS
This work demonstrated that the aqueous extract of Moroccan propolis exhibited a significant antihyperglycemic effect in diabetic rats. Histopathological data demonstrated that propolis acts positively on the liver of diabetic rats. In addition, the preliminary phytochemical screening revealed that Moroccan propolis contains several phytochemicals. Finally, Moroccan propolis had a potent antioxidant activity which may be due to the richness in polyphenols content (90.91 mg EAG/1 g of extract).
CONCLUSION
The present study shows that Moroccan propolis from the hot desert region possesses a potent antihyperglycemic effect.
目的
本研究旨在评估摩洛哥撒哈拉地区蜂胶的降血糖活性。
背景
蜂胶自古以来就因其对健康的有益作用而闻名。
目的
本研究旨在评估来自沙漠地区的摩洛哥蜂胶水提物对血糖和脂代谢的影响。
方法
在链脲佐菌素诱导的糖尿病大鼠中评估摩洛哥蜂胶水提物的降血糖和抗脂解活性。在急性（6h）和亚慢性治疗期间监测血糖。此外，还评估了肝组织病理学分析和血清脂质谱以及葡萄糖耐量。
结果
本工作表明，摩洛哥蜂胶水提物在糖尿病大鼠中表现出显著的降血糖作用。组织病理学数据表明，蜂胶对糖尿病大鼠的肝脏有积极作用。此外，初步的植物化学筛选表明，摩洛哥蜂胶含有几种植物化学物质。最后，摩洛哥蜂胶具有很强的抗氧化活性，这可能是由于多酚含量丰富（每克提取物含有 90.91 毫克 EGCG）。
结论
本研究表明，来自炎热沙漠地区的摩洛哥蜂胶具有很强的降血糖作用。
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