用于同源靶向双模式成像和联合治疗的癌细胞膜仿生纳米系统。
Cancer cell membrane biomimetic nanosystem for homologous targeted dual-mode imaging and combined therapy.
机构信息
State Key Laboratory of Supramolecular Structure and Material, College of Chemistry, Jilin University, Changchun 130012, China.
Breast Surgery Department, China- Japan Union hospital of Jilin University, China.
出版信息
J Colloid Interface Sci. 2023 Dec 15;652(Pt A):770-779. doi: 10.1016/j.jcis.2023.08.109. Epub 2023 Aug 18.
HYPOTHESIS
The use of tumor cell membrane-camouflaged nanoparticles, specifically the multifunctional biomimetic core-shell nanosystem MPCONPs, can enhance the targeting ability and immune escape functionality of traditional chemotherapy, leading to more precise drug delivery and improved treatment outcomes.
EXPERIMENTS
Preparation of MPCONPs: Autologous tumor cell membrane (CM) fragments are collected and used to create a shell for the nanoparticles. A trypsin-sensitive cationic polylysine framework is synthesized and embedded with oxaliplatin (l-OHP) and Ce6-AuNDs (a singlet oxygen generator). The MPCONPs are formed by assembling these components.
FINDINGS
MPCONPs, as nanoparticles camouflaged with tumor CM, have enhanced cellular uptake in cancer cells and improved the efficacy of photodynamic therapy (PDT) and chemotherapy (CT). This offers great potential for their use as individualized therapeutic agents for clinical oncology treatment.
假设
利用肿瘤细胞膜伪装的纳米颗粒，特别是多功能仿生核壳纳米系统 MPCONPs，可以增强传统化疗的靶向能力和免疫逃逸功能，从而实现更精确的药物输送和改善治疗效果。
实验
MPCONPs 的制备：收集自体肿瘤细胞膜（CM）碎片，用于为纳米颗粒制造外壳。合成一种胰蛋白酶敏感的阳离子聚赖氨酸框架，并嵌入奥沙利铂（l-OHP）和 Ce6-AuNDs（单线态氧发生器）。通过组装这些成分形成 MPCONPs。
发现
作为肿瘤 CM 伪装的纳米颗粒，MPCONPs 增强了癌细胞对其的摄取，并提高了光动力疗法（PDT）和化学疗法（CT）的疗效。这为将其作为临床肿瘤治疗的个体化治疗剂提供了巨大的潜力。
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