Shao Sufang, Zhang Deling, Lin Bin, Han Yifeng
Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Dec 15;303:123284. doi: 10.1016/j.saa.2023.123284. Epub 2023 Aug 19.
Phosgene is an important and widely used highly toxic chemical that poses a serious potential threat to public health and property if leaked or abused. Therefore, developing an efficient and convenient detection method for phosgene is of great significance. In this work, we synthesized a novel fluorescent probe, BCyP, based on benzohemicyanine for highly selective and sensitive detection of phosgene in both liquid and gas phases. The probe uses amino alcohol as a specific recognition group for phosgene and does not fluoresce due to the strong intramolecular charge transfer effect (ICT). However, in the presence of phosgene, the amino alcohol part in the probe can form oxazolidinone in situ with phosgene, reducing the ICT effect in the probe molecule and lighting fluorescence, thus realizing the selective phosgene detection. The probe exhibits good specificity towards phosgene, with significant fluorescence enhancement (approximately 400-fold), a remarkable Stokes shift (139 nm), a fast response speed (less than 17 s), and a low detection limit (0.12 ppm). Additionally, we prepared a phosgene detection paper strip loaded with the probe on filter paper and combined it with color recognition software on a smartphone to achieve visual detection of phosgene in the gas phase.
光气是一种重要且广泛使用的剧毒化学品，如果发生泄漏或滥用，会对公众健康和财产构成严重潜在威胁。因此，开发一种高效便捷的光气检测方法具有重要意义。在这项工作中，我们基于苯并半菁合成了一种新型荧光探针BCyP，用于在液相和气相中对光气进行高选择性和高灵敏度检测。该探针以氨基醇作为光气的特异性识别基团，由于强烈的分子内电荷转移效应（ICT）而不发荧光。然而，在光气存在下，探针中的氨基醇部分可与光气原位形成恶唑烷酮，降低探针分子中的ICT效应并发出荧光，从而实现对光气的选择性检测。该探针对光气表现出良好的特异性，具有显著的荧光增强（约400倍）、明显的斯托克斯位移（139 nm）、快速的响应速度（小于17秒）和低检测限（0.12 ppm）。此外，我们在滤纸上制备了负载该探针的光气检测试纸条，并将其与智能手机上的颜色识别软件相结合，实现了气相中光气的可视化检测。
