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主动脉夹层中的生物标志物:临床研究的诊断和预后价值

Biomarkers in aortic dissection: Diagnostic and prognostic value from clinical research.

作者信息

Zhao Yufei, Fu Weiguo, Wang Lixin

机构信息

Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Vascular Surgery Institute,Zhongshan Hospital, Fudan University, Shanghai 200032, China.

出版信息

Chin Med J (Engl). 2024 Feb 5;137(3):257-269. doi: 10.1097/CM9.0000000000002719. Epub 2023 Aug 24.

Abstract

Aortic dissection is a life-threatening condition for which diagnosis mainly relies on imaging examinations, while reliable biomarkers to detect or monitor are still under investigation. Recent advances in technologies provide an unprecedented opportunity to yield the identification of clinically valuable biomarkers, including proteins, ribonucleic acids (RNAs), and deoxyribonucleic acids (DNAs), for early detection of pathological changes in susceptible patients, rapid diagnosis at the bedside after onset, and a superior therapeutic regimen primarily within the concept of personalized and tailored endovascular therapy for aortic dissection.

摘要

主动脉夹层是一种危及生命的疾病,其诊断主要依赖于影像学检查,而用于检测或监测的可靠生物标志物仍在研究中。技术的最新进展提供了前所未有的机会,以鉴定包括蛋白质、核糖核酸(RNA)和脱氧核糖核酸(DNA)在内的具有临床价值的生物标志物,用于早期检测易感患者的病理变化、发病后在床边进行快速诊断,以及主要在个性化和定制化血管内治疗主动脉夹层的概念范围内制定更优的治疗方案。

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