Saad Bashar
Al-Qasemi Academic College, Baqa Algharbiya 30100, Israel.
Department of Biochemistry, Faculty of Medicine, The Arab American University, Jenin P203, Palestine.
Biomedicines. 2023 Aug 5;11(8):2204. doi: 10.3390/biomedicines11082204.
Inflammation is a crucial factor in the development and progression of cardiovascular diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to myocardial fibrosis and extracellular matrix changes, which reduce cardiac function, induce arrhythmias, and finally, cause heart failure. The majority of current CVD treatment plans concentrate on reducing risk factors such as hyperlipidemia, type 2 diabetes, and hypertension. One such strategy could be inflammation reduction. Numerous in vitro, animal, and clinical studies indicate that obesity is associated with low-grade inflammation. Recent studies have demonstrated the potential of medicinal plants and phytochemicals to cure and prevent obesity and inflammation. In comparison to conventional therapies, the synergistic effects of several phytochemicals boost their bioavailability and impact numerous cellular and molecular targets. Focusing on appetite, pancreatic lipase activity, thermogenesis, lipid metabolism, lipolysis and adipogenesis, apoptosis in adipocytes, and adipocyte life cycle by medicinal plants and phytochemicals represent an important goal in the development of new anti-obesity drugs. We conducted an extensive review of the literature and electronic databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus, for collecting data on the therapeutic effects of medicinal plants/phytochemicals in curing obesity and its related inflammation and CVD diseases, including cellular and molecular mechanisms, cytokines, signal transduction cascades, and clinical trials.
炎症是心血管疾病（CVD）发生和发展的关键因素。持续性炎症状态下的心脏重塑会导致心肌纤维化和细胞外基质变化，进而降低心脏功能、诱发心律失常，并最终导致心力衰竭。目前大多数CVD治疗方案都集中在降低诸如高脂血症、2型糖尿病和高血压等风险因素上。其中一种策略可能是减轻炎症。大量的体外、动物和临床研究表明，肥胖与低度炎症有关。最近的研究已经证明了药用植物和植物化学物质在治疗和预防肥胖及炎症方面的潜力。与传统疗法相比，几种植物化学物质的协同作用提高了它们的生物利用度，并影响众多细胞和分子靶点。通过药用植物和植物化学物质关注食欲、胰脂肪酶活性、产热、脂质代谢、脂肪分解和脂肪生成、脂肪细胞凋亡以及脂肪细胞生命周期，是开发新型抗肥胖药物的一个重要目标。我们对文献和电子数据库进行了广泛的综述，包括谷歌学术、PubMed、科学Direct和MedlinePlus，以收集关于药用植物/植物化学物质在治疗肥胖及其相关炎症和CVD疾病方面的治疗效果的数据，包括细胞和分子机制、细胞因子、信号转导级联反应和临床试验。
