Guo Xu, Zhang Yingying, Pan Yang, Yang Kankan, Tong Xinxin, Wang Yong
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen 518000, China.
Animals (Basel). 2023 Aug 14;13(16):2617. doi: 10.3390/ani13162617.
Chaphamaparvoviruses (ChPVs) are ancient viruses that have been detected in a variety of hosts. In this study, through a phylogenetic analysis and the adaptability of ChPV to multiple hosts, we evaluated the basis for the ability of feline (FeChPV) and canine ChPV (CaChPV) for cross-species transmission. Phylogenetic analysis showed that FeChPV and CaChPV were closely related. Notably, two strains of ChPVs isolated from domestic cats and two from dogs clustered together with CaChPVs and FeChPVs, respectively, suggesting that the stringent boundaries between canine and feline ChPV may be broken. Further analysis revealed that CaChPV and FeChPV were more adapted to dogs than to cats. Mutation analysis identified several shared mutations in cross-species-transmissible strains. Furthermore, the VP structures of FeChPV and CaChPV exhibited a high degree of similarity across both cross-species-transmissible and non-cross-species-transmissible strains. However, it is crucial to note that these results are largely computational, and limitations exist in terms of the number and diversity of samples analyzed; the capacity for cross-species transmission should be approached with caution and elucidated in further studies.
查帕马细小病毒（ChPVs）是在多种宿主中被检测到的古老病毒。在本研究中，通过系统发育分析以及ChPV对多种宿主的适应性，我们评估了猫细小病毒（FeChPV）和犬细小病毒（CaChPV）跨物种传播能力的基础。系统发育分析表明，FeChPV和CaChPV密切相关。值得注意的是，从家猫中分离出的两株ChPVs和从狗中分离出的两株ChPVs分别与CaChPVs和FeChPVs聚类在一起，这表明犬类和猫类ChPV之间严格的界限可能被打破。进一步分析表明，CaChPV和FeChPV对狗的适应性比对猫更强。突变分析确定了跨物种传播菌株中的几个共同突变。此外，FeChPV和CaChPV的VP结构在跨物种传播和非跨物种传播菌株中都表现出高度相似性。然而，必须指出的是，这些结果在很大程度上是基于计算的，并且在分析的样本数量和多样性方面存在局限性；跨物种传播能力应谨慎对待，并在进一步研究中阐明。
