Department of Biology, Union University, Jackson, TN 38305, USA.
Department of Bioinformatics and Biosystems, Seongnam Campus of Korea Polytechnics, Seongnam-si 13122, Republic of Korea.
Int J Mol Sci. 2023 Aug 16;24(16):12836. doi: 10.3390/ijms241612836.
There is a growing body of evidence supporting the significant role of bacterial biofilms in the pathogenesis of various human diseases, including cancer. Biofilms are polymicrobial communities enclosed within an extracellular matrix composed of polysaccharides, proteins, extracellular DNA, and lipids. This complex matrix provides protection against antibiotics and host immune responses, enabling the microorganisms to establish persistent infections. Moreover, biofilms induce anti-inflammatory responses and metabolic changes in the host, further facilitating their survival. Many of these changes are comparable to those observed in cancer cells. This review will cover recent research on the role of bacterial biofilms in carcinogenesis, especially in colorectal (CRC) and gastric cancers, emphasizing the shared physical and chemical characteristics of biofilms and cancer. This review will also discuss the interactions between bacteria and the tumor microenvironment, which can facilitate oncogene expression and cancer progression. This information will provide insight into developing new therapies to identify and treat biofilm-associated cancers, such as utilizing bacteria as delivery vectors, using bacteria to upregulate immune function, or more selectively targeting biofilms and cancer for their shared traits.
越来越多的证据表明，细菌生物膜在各种人类疾病（包括癌症）的发病机制中起着重要作用。生物膜是由多糖、蛋白质、细胞外 DNA 和脂质组成的细胞外基质包裹的多微生物群落。这种复杂的基质提供了对抗生素和宿主免疫反应的保护，使微生物能够建立持续的感染。此外，生物膜在宿主中诱导抗炎反应和代谢变化，进一步促进其存活。其中许多变化与癌细胞中观察到的变化相似。这篇综述将涵盖细菌生物膜在致癌作用中的最新研究，特别是在结直肠癌（CRC）和胃癌中的作用，强调生物膜和癌症的共同理化特性。本文还将讨论细菌与肿瘤微环境之间的相互作用，这有助于癌基因的表达和癌症的进展。这些信息将为开发新的治疗方法提供思路，以识别和治疗与生物膜相关的癌症，例如利用细菌作为递药载体，利用细菌上调免疫功能，或更有针对性地针对生物膜和癌症的共同特征进行治疗。
