阻塞性睡眠呼吸暂停、慢性阻塞性肺疾病和充血性心力衰竭之间的相互作用：是否应该将它们统称为三重重叠综合征？
The Interplay between Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, and Congestive Heart Failure: Time to Collectively Refer to Them as Triple Overlap Syndrome?
机构信息
Internal Medicine, Manipal College of Medical Sciences, Pokhara 33700, Nepal.
Internal Medicine, Institute of Medicine, Kathmandu 44600, Nepal.
出版信息
Medicina (Kaunas). 2023 Jul 27;59(8):1374. doi: 10.3390/medicina59081374.
BACKGROUND AND OBJECTIVES
Obstructive sleep apnea-hypopnea syndrome (OSAHS) and chronic obstructive pulmonary disease (COPD) are independently linked to an increase in cardiovascular disease (CVD). Only a few studies have been published linking the association between overlap syndrome and congestive heart failure (CHF). This review highlights the interplay between overlap syndrome (OSAHS-COPD) and CHF.
MATERIALS AND METHODS
We thoroughly reviewed published literature from 2005 to 2022 in PubMed, Google Scholar, and Cochrane databases to explore the link between overlap syndrome and cardiovascular outcomes, specifically congestive heart failure.
RESULTS
Research indicates that individuals with overlap syndrome are more likely to develop congestive heart failure than those with COPD or OSA alone. Congestive heart failure is a common comorbidity of overlap syndrome, and it has a two-way connection with sleep-related breathing disorders, which tend to occur together more frequently than expected by chance.
CONCLUSIONS
CHF seems to have a strong relationship with OS. Further research is required to understand the relationship between OS and CHF.
背景与目的
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）和慢性阻塞性肺疾病（COPD）均与心血管疾病（CVD）的发生风险增加独立相关。仅有少数研究报道了重叠综合征与充血性心力衰竭（CHF）之间的关联。本综述强调了重叠综合征（OSAHS-COPD）与 CHF 之间的相互作用。
材料与方法
我们全面检索了 2005 年至 2022 年在 PubMed、Google Scholar 和 Cochrane 数据库中发表的文献，以探讨重叠综合征与心血管结局（特别是充血性心力衰竭）之间的关系。
结果
研究表明，重叠综合征患者发生充血性心力衰竭的风险高于单纯 COPD 或 OSA 患者。充血性心力衰竭是重叠综合征的常见合并症，它与睡眠相关呼吸障碍之间存在双向关联，这种关联比预期的随机事件更频繁地发生。
结论
CHF 似乎与 OS 有很强的关系。需要进一步研究以了解 OS 和 CHF 之间的关系。
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