Department of Control Theory and System Dynamics, Neurotechnology Department, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russia.
Center for Biomedical Technology, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, Spain.
Sensors (Basel). 2023 Aug 8;23(16):7016. doi: 10.3390/s23167016.
We present a novel closed-loop system designed to integrate biological and artificial neurons of the oscillatory type into a unified circuit. The system comprises an electronic circuit based on the FitzHugh-Nagumo model, which provides stimulation to living neurons in acute hippocampal mouse brain slices. The local field potentials generated by the living neurons trigger a transition in the FitzHugh-Nagumo circuit from an excitable state to an oscillatory mode, and in turn, the spikes produced by the electronic circuit synchronize with the living-neuron spikes. The key advantage of this hybrid electrobiological autogenerator lies in its capability to control biological neuron signals, which holds significant promise for diverse neuromorphic applications.
我们提出了一种新颖的闭环系统，旨在将生物和人工振荡型神经元集成到一个统一的电路中。该系统由一个基于 FitzHugh-Nagumo 模型的电子电路组成，该电路可以对急性海马脑片上的活神经元进行刺激。活神经元产生的局部场电位使 FitzHugh-Nagumo 电路从兴奋状态转变为振荡模式，而电子电路产生的尖峰则与活神经元的尖峰同步。这种混合电生物自发生器的关键优势在于它能够控制生物神经元信号，这为各种神经形态应用带来了巨大的前景。
