Wildlife Disease Response Team, National Institute of Wildlife Disease Control and Prevention (NIWDC), 1 Songam-gil, Gwangsan-gu, Gwangju 62407, Republic of Korea.
Viruses. 2023 Jul 31;15(8):1667. doi: 10.3390/v15081667.
African swine fever (ASF), a viral disease caused by the African swine fever virus (ASFV), is associated with high mortality rates in domestic pigs and wild boars. ASF has been spreading since its discovery in wild boars in Korea in October 2019. Genomic analyses have provided insights into the genetic diversity of the ASFV isolated from various regions, enabling a better understanding of the virus origin and transmission patterns. We conducted a genome analysis to evaluate the diversity and mutations of ASFV spreading among wild boars in Korea during 2019-2022. We compared the genomes of ASFV strains isolated from Korean wild boars and publicly available ASFV genomes. Genomic analysis revealed several single-nucleotide polymorphisms within multigene families (MGFs) 360-1La and 360-4L in Korean ASFV. MGF 360-1La and 360-4L variations were not observed in other ASFV strains, including those of genotype II. Finally, we partially analyzed MGFs 360-1La and 360-4L in ASFV-positive samples between 2019 and 2022, confirming the geographical distribution of the variants. Our findings can help identify new genetic markers for epidemiological ASFV analysis and provide essential information for effective disease management.
非洲猪瘟（ASF）是由非洲猪瘟病毒（ASFV）引起的一种病毒性疾病，在家猪和野猪中死亡率很高。自 2019 年 10 月在韩国野猪中发现以来，ASF 一直在传播。基因组分析深入了解了从不同地区分离出的 ASFV 的遗传多样性，有助于更好地了解病毒的起源和传播模式。我们进行了基因组分析，以评估 2019 年至 2022 年期间韩国野猪中传播的 ASFV 的多样性和突变。我们比较了从韩国野猪中分离出的 ASFV 菌株和公开的 ASFV 基因组。基因组分析揭示了韩国 ASFV 中多基因家族（MGF）360-1La 和 360-4L 内的几个单核苷酸多态性。在其他 ASFV 株中，包括基因型 II 株，未观察到 MGF 360-1La 和 360-4L 的变异。最后，我们在 2019 年至 2022 年间对 ASFV 阳性样本中的 MGF 360-1La 和 360-4L 进行了部分分析，证实了变异体的地理分布。我们的研究结果有助于确定用于流行病学 ASFV 分析的新遗传标记，并为有效疾病管理提供重要信息。
