Kim Garam, Park Jung-Eun, Kim So-Jeong, Kim Yeonji, Kim Wonjun, Kim Yong-Kwan, Jheong WeonHwa
Wildlife Disease Response Team, National Institute of Wildlife Disease Control and Prevention (NIWDC), Gwangju, Republic of Korea.
Front Vet Sci. 2023 Jan 11;9:1080397. doi: 10.3389/fvets.2022.1080397. eCollection 2022.
African swine fever (ASF), a highly contagious and severe hemorrhagic viral disease in swine, is emerging as a major threat not only in Korea but also worldwide. The first confirmed case of ASF in Korea was reported in 2019. Despite the occurrence of ASF in Korea, only a few studies have genetically characterized the causative ASF virus (ASFV). In this study, we aimed to genetically characterize the ASFV responsible for the 2019 outbreak in Korea. The genome of the ASFV isolated during the first outbreak in Korea was analyzed. The Korea/YC1/2019 strain has 188,950 base pairs, with a GC content of 38.4%. The complete genome sequence was compared with other ASFV genomes annotated in the NCBI database. The Korea/YC1/2019 strain shared the highest similarity with Georgia 2007, Belgium 2018/1, and ASFV-wbBS01 strains. This study expands our knowledge of the genetic diversity of ASFV, providing valuable information for epidemiology, diagnostics, therapies, and vaccine development.
非洲猪瘟（ASF）是一种猪的高度传染性和严重性出血性病毒病，不仅在韩国，而且在全球范围内都正成为一个重大威胁。韩国首例ASF确诊病例于2019年报告。尽管韩国出现了ASF，但只有少数研究对致病性非洲猪瘟病毒（ASFV）进行了基因特征分析。在本研究中，我们旨在对导致2019年韩国疫情爆发的ASFV进行基因特征分析。分析了在韩国首次疫情爆发期间分离出的ASFV基因组。韩国/YC1/2019毒株有188,950个碱基对，GC含量为38.4%。将完整的基因组序列与NCBI数据库中注释的其他ASFV基因组进行了比较。韩国/YC1/2019毒株与格鲁吉亚2007、比利时2018/1和ASFV-wbBS01毒株具有最高的相似性。本研究扩展了我们对ASFV基因多样性的认识，为流行病学、诊断、治疗和疫苗开发提供了有价值的信息。
