Han Hye Sung, Kim Bo Ri, Kim Minjae, Na Jung-Im, Seo Suk Bae, Huh Chang-Hun, Shin Jung-Won
Department of Dermatology, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Gyeonggi-do, Korea.
Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
Lasers Surg Med. 2023 Nov;55(9):809-816. doi: 10.1002/lsm.23719. Epub 2023 Aug 26.
A needleless laser-induced microjet injector is a novel transdermal drug delivery system that can rapidly inject a very small and precise drug dose into the skin with minimal pain and downtime. In this study, we aimed to compare the laser-induced microjet injection versus needle injection of polylactic acid/hyaluronic acid filler for skin enhancement and rejuvenation.
A 24-week prospective, single-center, assessor-blinded, randomized, split-face study was conducted. The enrolled patients underwent one treatment session of dermal filler injection using a laser-induced microjet injector on one half of the face or a traditional needle injection on the other half of the face. Evaluation was conducted at baseline before treatment and at 4, 12, and 24 weeks after treatment.
A single treatment of filler injection with a laser-induced microjet injector resulted in similar improvements in skin hydration and elasticity as a single treatment of filler injection by using manual needle injection, with reduced pain, side effects, and decreased treatment time.
Laser-induced microjet injector enabled not only the application of a controlled dose and filler depth but also even distribution, improved clinical efficacy, reduced pain and side effects, and sufficient time for clinicians to perform treatment.
无针激光诱导微射流注射器是一种新型的经皮给药系统，它能够以最小的疼痛和停工期，将非常小且精确的药物剂量快速注入皮肤。在本研究中，我们旨在比较激光诱导微射流注射与针剂注射聚乳酸/透明质酸填充剂用于皮肤改善和年轻化的效果。
进行了一项为期24周的前瞻性、单中心、评估者盲法、随机、半脸研究。入选患者在面部的一半使用激光诱导微射流注射器进行一次真皮填充剂注射治疗，在面部的另一半进行传统针剂注射治疗。在治疗前的基线以及治疗后4周、12周和24周进行评估。
与使用手动针剂注射进行一次填充剂注射相比，使用激光诱导微射流注射器进行一次填充剂注射在皮肤水合作用和弹性方面产生了相似的改善，同时疼痛、副作用减轻，治疗时间缩短。
激光诱导微射流注射器不仅能够实现可控剂量和填充剂深度的应用，还能实现均匀分布，提高临床疗效，减轻疼痛和副作用，为临床医生提供足够的时间进行治疗。
